ENSG00000163909


Homo sapiens

Features
Gene ID: ENSG00000163909
  
Biological name :HEYL
  
Synonyms : hes related family bHLH transcription factor with YRPW motif-like / HEYL / Q9NQ87
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.2
Gene start: 39624153
Gene end: 39639945
  
Corresponding Affymetrix probe sets: 220662_s_at (Human Genome U133 Plus 2.0 Array)   226828_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361943
RefSeq - NM_014571
RefSeq - XM_005270745
RefSeq Peptide - NP_055386
swissprot - Q9NQ87
Ensembl - ENSG00000163909
  

This gene has been taged as a transcription factor by TFT
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 heylENSDARG00000055798Danio rerio
 HEYLENSGALG00000044737Gallus gallus
 HeylENSMUSG00000032744Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HEY2 / Q9UBP5 / hes related family bHLH transcription factor with YRPW motif 2ENSG0000013554741
HEY1 / Q9Y5J3 / hes related family bHLH transcription factor with YRPW motif 1ENSG0000016468340
HELT / A6NFD8 / helt bHLH transcription factorENSG0000018782120


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IEA
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003208 cardiac ventricle morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014031 mesenchymal cell development IEA
 biological_processGO:0032835 glomerulus development IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IDA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0072014 proximal tubule development IEA
 biological_processGO:2000824 negative regulation of androgen receptor activity IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0035939 microsatellite binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0050683 AF-1 domain binding IPI


Pathways (from Reactome)
Pathway description
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH3 Intracellular Domain Regulates Transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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