ENSG00000187821


Homo sapiens

Features
Gene ID: ENSG00000187821
  
Biological name :HELT
  
Synonyms : A6NFD8 / HELT / helt bHLH transcription factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q35.1
Gene start: 185018841
Gene end: 185020804
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000343464
Ensembl peptide - ENSP00000426033
Ensembl peptide - ENSP00000422140
NCBI entrez gene - 391723     See in Manteia.
OMIM - 617546
RefSeq - NM_001300781
RefSeq - NM_001300782
RefSeq Peptide - NP_001287711
RefSeq Peptide - NP_001287710
swissprot - A6NFD8
swissprot - A0A087WSW0
Ensembl - ENSG00000187821
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 heltENSDARG00000056400Danio rerio
 HeltENSMUSG00000047171Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HEY1 / Q9Y5J3 / hes related family bHLH transcription factor with YRPW motif 1ENSG0000016468329
HEYL / Q9NQ87 / hes related family bHLH transcription factor with YRPW motif-likeENSG0000016390926
HEY2 / Q9UBP5 / hes related family bHLH transcription factor with YRPW motif 2ENSG0000013554726


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0010467 gene expression IEA
 biological_processGO:0021858 GABAergic neuron differentiation in basal ganglia IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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