ENSG00000164327


Homo sapiens

Features
Gene ID: ENSG00000164327
  
Biological name :RICTOR
  
Synonyms : Q6R327 / RICTOR / RPTOR independent companion of MTOR complex 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p13.1
Gene start: 38937919
Gene end: 39074408
  
Corresponding Affymetrix probe sets: 1552734_at (Human Genome U133 Plus 2.0 Array)   226310_at (Human Genome U133 Plus 2.0 Array)   226312_at (Human Genome U133 Plus 2.0 Array)   228248_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423162
Ensembl peptide - ENSP00000296782
Ensembl peptide - ENSP00000349959
Ensembl peptide - ENSP00000423019
NCBI entrez gene - 253260     See in Manteia.
OMIM - 609022
RefSeq - XM_017009315
RefSeq - NM_001285439
RefSeq - NM_001285440
RefSeq - NM_152756
RefSeq - XM_011514006
RefSeq - XM_017009311
RefSeq - XM_017009312
RefSeq - XM_017009313
RefSeq - XM_017009314
RefSeq - XM_006714463
RefSeq - XM_011514005
RefSeq Peptide - NP_001272368
RefSeq Peptide - NP_001272369
RefSeq Peptide - NP_689969
swissprot - Q6R327
swissprot - D6R9S6
Ensembl - ENSG00000164327
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rictoraENSDARG00000100867Danio rerio
 rictorbENSDARG00000002020Danio rerio
 RICTORENSGALG00000003775Gallus gallus
 Q6QI06ENSMUSG00000050310Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR028267  Rapamycin-insensitive companion of mTOR, N-terminal domain
 IPR028268  Pianissimo family
 IPR029259  Rapamycin-insensitive companion of mTOR, phosphorylation-site
 IPR029451  Rapamycin-insensitive companion of mTOR, middle domain
 IPR029452  Rapamycin-insensitive companion of mTOR, domain 5
 IPR029453  Rapamycin-insensitive companion of mTOR, domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009792 embryo development ending in birth or egg hatching IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IGI
 biological_processGO:0030010 establishment of cell polarity IBA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0030950 establishment or maintenance of actin cytoskeleton polarity IBA
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032008 positive regulation of TOR signaling IMP
 biological_processGO:0032148 activation of protein kinase B activity TAS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051896 regulation of protein kinase B signaling IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031932 TORC2 complex IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IBA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043022 ribosome binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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