ENSMUSG00000050310


Mus musculus

Features
Gene ID: ENSMUSG00000050310
  
Biological name :Rictor
  
Synonyms : Q6QI06 / Rictor / RPTOR independent companion of MTOR, complex 2
  
Possible biological names infered from orthology : Q6R327
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 6708379
Gene end: 6800401
  
Corresponding Affymetrix probe sets: 10422781 (MoGene1.0st)   1427583_at (Mouse Genome 430 2.0 Array)   1429810_at (Mouse Genome 430 2.0 Array)   1435698_at (Mouse Genome 430 2.0 Array)   1441753_at (Mouse Genome 430 2.0 Array)   1453775_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051809
NCBI entrez gene - 78757     See in Manteia.
MGI - MGI:1926007
RefSeq - XM_006520004
RefSeq - NM_030168
RefSeq - XM_006520003
RefSeq Peptide - NP_084444
swissprot - Q6QI06
Ensembl - ENSMUSG00000050310
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rictoraENSDARG00000100867Danio rerio
 rictorbENSDARG00000002020Danio rerio
 RICTORENSGALG00000003775Gallus gallus
 Q6R327ENSG00000164327Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR028267  Rapamycin-insensitive companion of mTOR, N-terminal domain
 IPR028268  Pianissimo family
 IPR029259  Rapamycin-insensitive companion of mTOR, phosphorylation-site
 IPR029451  Rapamycin-insensitive companion of mTOR, middle domain
 IPR029452  Rapamycin-insensitive companion of mTOR, domain 5
 IPR029453  Rapamycin-insensitive companion of mTOR, domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009792 embryo development ending in birth or egg hatching IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0030950 establishment or maintenance of actin cytoskeleton polarity IBA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0051896 regulation of protein kinase B signaling IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 cellular_componentGO:0031932 TORC2 complex ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IBA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043022 ribosome binding IDA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

 MP:0000659 prostate gland hyperplasia "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Ptentm1Rps/Pten+,RictorGt(RRR347)Byg/Rictor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Rictortm1.2Mgn/Rictortm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Rictortm1.3Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0001711 abnormal placenta 
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

Allelic Composition: Rictortm1.2Mgn/Rictortm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Rictortm1.3Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Rps/Pten+,RictorGt(RRR347)Byg/Rictor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rictortm1Rueg/Rictortm1Rueg,Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rictortm1Rueg/Rictortm1Rueg,Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rictortm1Rueg/Rictortm1Rueg,Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

 MP:0004702 increased circulating insulin-like growth factor I level "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rictortm1.2Mgn/Rictortm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Rictortm1.3Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0009734 abnormal prostate gland duct morphology "any structural anomaly of the minute canals that pass the prostatic secretions to the urethra" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010132 decreased DN2 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010134 decreased DN3 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Rictortm1.2Mgn/Rictortm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Rictortm1.3Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: RictorGt(RRR347)Byg/RictorGt(RRR347)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0011524 thick placenta labyrinth "increase in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: RictorGt(RRR347)Byg/RictorGt(RRR347)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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