ENSG00000164587


Homo sapiens

Features
Gene ID: ENSG00000164587
  
Biological name :RPS14
  
Synonyms : P62263 / ribosomal protein S14 / RPS14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q33.1
Gene start: 150442635
Gene end: 150449756
  
Corresponding Affymetrix probe sets: 208645_s_at (Human Genome U133 Plus 2.0 Array)   208646_at (Human Genome U133 Plus 2.0 Array)   214245_at (Human Genome U133 Plus 2.0 Array)   217298_at (Human Genome U133 Plus 2.0 Array)   241241_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000311028
Ensembl peptide - ENSP00000428509
Ensembl peptide - ENSP00000496665
Ensembl peptide - ENSP00000429856
Ensembl peptide - ENSP00000385425
Ensembl peptide - ENSP00000385958
NCBI entrez gene - 6208     See in Manteia.
OMIM - 130620
RefSeq - XM_017009684
RefSeq - NM_001025070
RefSeq - NM_001025071
RefSeq - NM_005617
RefSeq Peptide - NP_001020241
RefSeq Peptide - NP_001020242
RefSeq Peptide - NP_005608
swissprot - P62263
swissprot - E5RH77
Ensembl - ENSG00000164587
  
Related genetic diseases (OMIM): 153550 - Macrocytic anemia, refractory, due to 5q deletion, somatic, 153550
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps14ENSDARG00000036629Danio rerio
 RPS14ENSGALG00000004588Gallus gallus
 Rps14ENSMUSG00000024608Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001971  Ribosomal protein S11
 IPR018102  Ribosomal S11, conserved site
 IPR036967  Ribosomal protein S11 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000028 ribosomal small subunit assembly ISS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS
 biological_processGO:0019083 viral transcription TAS
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030490 maturation of SSU-rRNA ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding ISS
 molecular_functionGO:0003735 structural constituent of ribosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045182 translation regulator activity IMP
 molecular_functionGO:0048027 mRNA 5"-UTR binding IDA
 molecular_functionGO:0070181 small ribosomal subunit rRNA binding IBA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001428 Somatic mutation 
Show

 HP:0001452 Autosomal dominant contiguous gene syndrome 
Show

 HP:0002863 Myelodysplasia 
Show

 HP:0003745 Sporadic 
Show

 HP:0004861 refractory macrocytic anemia 
Show

 HP:0012133 Erythroid hypoplasia "Decreased count of erythroid precursor cells, that is, `erythroid lineage cells` (CL:0000764) in the bone marrow." [DDD:akelly]
Show

 HP:0012143 Abnormality of cells of the megakaryocyte lineage "Anomaly of `megakaryocytes` (CL:0000556)." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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