ENSG00000166508


Homo sapiens

Features
Gene ID: ENSG00000166508
  
Biological name :MCM7
  
Synonyms : MCM7 / minichromosome maintenance complex component 7 / P33993
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.1
Gene start: 100092728
Gene end: 100101940
  
Corresponding Affymetrix probe sets: 208795_s_at (Human Genome U133 Plus 2.0 Array)   210983_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411295
Ensembl peptide - ENSP00000346171
Ensembl peptide - ENSP00000445904
Ensembl peptide - ENSP00000483795
Ensembl peptide - ENSP00000307288
Ensembl peptide - ENSP00000344006
NCBI entrez gene - 4176     See in Manteia.
OMIM - 600592
RefSeq - XM_017012217
RefSeq - NM_001278595
RefSeq - NM_005916
RefSeq - NM_182776
RefSeq - XM_005250348
RefSeq Peptide - NP_005907
RefSeq Peptide - NP_877577
RefSeq Peptide - NP_001265524
swissprot - P33993
swissprot - C9J8M6
swissprot - A0A0S2Z4A5
swissprot - H0YH42
Ensembl - ENSG00000166508
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm7ENSDARG00000101180Danio rerio
 Mcm7ENSMUSG00000029730Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MCM9 / Q9NXL9 / minichromosome maintenance 9 homologous recombination repair factorENSG0000011187730


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR003593  AAA+ ATPase domain
 IPR008050  DNA replication licensing factor Mcm7
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006268 DNA unwinding involved in DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0042325 regulation of phosphorylation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071466 cellular response to xenobiotic stimulus IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000785 chromatin TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0042555 MCM complex IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000076003 MCM6 / Q14566 / minichromosome maintenance complex component 6  / complex
 ENSG00000104738 MCM4 / P33991 / minichromosome maintenance complex component 4  / complex






 

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