ENSG00000166855


Homo sapiens

Features
Gene ID: ENSG00000166855
  
Biological name :CLPX
  
Synonyms : caseinolytic mitochondrial matrix peptidase chaperone subunit / CLPX / O76031
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q22.31
Gene start: 65148219
Gene end: 65185342
  
Corresponding Affymetrix probe sets: 204809_at (Human Genome U133 Plus 2.0 Array)   223507_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453461
Ensembl peptide - ENSP00000300107
Ensembl peptide - ENSP00000452611
NCBI entrez gene - 10845     See in Manteia.
OMIM - 615611
RefSeq - XM_011521164
RefSeq - NM_006660
RefSeq Peptide - NP_006651
swissprot - H0YM48
swissprot - A0A024R5X7
swissprot - O76031
swissprot - H0YK07
Ensembl - ENSG00000166855
  
Related genetic diseases (OMIM): 618015 - ?Protoporphyria, erythropoietic, 2, 618015
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clpxaENSDARG00000029063Danio rerio
 clpxbENSDARG00000067796Danio rerio
 CLPXENSGALG00000007289Gallus gallus
 ClpxENSMUSG00000015357Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR004487  Clp protease, ATP-binding subunit ClpX
 IPR019489  Clp ATPase, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0046034 ATP metabolic process IDA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0009368 endopeptidase Clp complex IDA
 cellular_componentGO:0009841 mitochondrial endopeptidase Clp complex IDA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004176 ATP-dependent peptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016504 peptidase activator activity IDA
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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