ENSG00000167264


Homo sapiens

Features
Gene ID: ENSG00000167264
  
Biological name :DUS2
  
Synonyms : dihydrouridine synthase 2 / DUS2 / Q9NX74
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 67987746
Gene end: 68079320
  
Corresponding Affymetrix probe sets: 219486_at (Human Genome U133 Plus 2.0 Array)   47105_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454424
Ensembl peptide - ENSP00000455229
Ensembl peptide - ENSP00000455977
Ensembl peptide - ENSP00000456261
Ensembl peptide - ENSP00000456677
Ensembl peptide - ENSP00000457292
Ensembl peptide - ENSP00000458152
Ensembl peptide - ENSP00000458906
Ensembl peptide - ENSP00000461244
Ensembl peptide - ENSP00000461659
Ensembl peptide - ENSP00000463498
Ensembl peptide - ENSP00000351769
Ensembl peptide - ENSP00000409498
Ensembl peptide - ENSP00000454252
NCBI entrez gene - 54920     See in Manteia.
OMIM - 609707
RefSeq - NM_001271763
RefSeq - NM_017803
RefSeq - NM_001271762
RefSeq Peptide - NP_001258691
RefSeq Peptide - NP_001258692
RefSeq Peptide - NP_060273
swissprot - Q9NX74
swissprot - A0A024R6Z7
swissprot - E7EUN9
swissprot - H3BM64
swissprot - H3BMK6
swissprot - H3BQX4
swissprot - H3BRI6
swissprot - H3BSF3
swissprot - H3BTR3
swissprot - I3L0K0
swissprot - I3L1K5
swissprot - I3L4H0
swissprot - I3L4Y9
swissprot - J3QLD5
Ensembl - ENSG00000167264
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dus2ENSDARG00000077607Danio rerio
 Dus2ENSMUSG00000031901Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001269  tRNA-dihydrouridine synthase
 IPR013785  Aldolase-type TIM barrel
 IPR014720  Double-stranded RNA-binding domain
 IPR018517  tRNA-dihydrouridine synthase, conserved site
 IPR035587  DUS-like, FMN-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002943 tRNA dihydrouridine synthesis IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060548 negative regulation of cell death IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0017150 tRNA dihydrouridine synthase activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
tRNA modification in the nucleus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136628 EPRS / P07814 / glutamyl-prolyl-tRNA synthetase  / complex






 

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