ENSG00000136628


Homo sapiens

Features
Gene ID: ENSG00000136628
  
Biological name :EPRS
  
Synonyms : EPRS / glutamyl-prolyl-tRNA synthetase / P07814
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q41
Gene start: 219968601
Gene end: 220046658
  
Corresponding Affymetrix probe sets: 200841_s_at (Human Genome U133 Plus 2.0 Array)   200842_s_at (Human Genome U133 Plus 2.0 Array)   200843_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355890
Ensembl peptide - ENSP00000477245
Ensembl peptide - ENSP00000477493
NCBI entrez gene - 2058     See in Manteia.
OMIM - 138295
RefSeq - XM_017000614
RefSeq - NM_004446
RefSeq Peptide - NP_004437
swissprot - P07814
swissprot - V9GYZ6
swissprot - V9GZ76
Ensembl - ENSG00000136628
  
Related genetic diseases (OMIM): 617951 - Leukodystrophy, hypomyelinating, 15, 617951
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eprsENSDARG00000060494Danio rerio
 EPRSENSGALG00000009598Gallus gallus
 EprsENSMUSG00000026615Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000738  WHEP-TRS domain
 IPR000924  Glutamyl/glutaminyl-tRNA synthetase
 IPR001412  Aminoacyl-tRNA synthetase, class I, conserved site
 IPR002314  Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
 IPR004046  Glutathione S-transferase, C-terminal
 IPR004154  Anticodon-binding
 IPR004499  Proline-tRNA ligase, class IIa, archaeal-type
 IPR004526  Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
 IPR006195  Aminoacyl-tRNA synthetase, class II
 IPR009068  S15/NS1, RNA-binding
 IPR011035  Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR016061  Proline-tRNA ligase, class II, C-terminal
 IPR017449  Prolyl-tRNA synthetase, class II
 IPR020056  Ribosomal protein L25/Gln-tRNA synthetase, N-terminal
 IPR020058  Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
 IPR020059  Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
 IPR020061  Glutamine-tRNA ligase, alpha-bundle domain superfamily
 IPR033721  Prolyl-tRNA synthetase, catalytic domain
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily
 IPR036621  Anticodon-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006424 glutamyl-tRNA aminoacylation IEA
 biological_processGO:0006433 prolyl-tRNA aminoacylation IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0043039 tRNA aminoacylation IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0017101 aminoacyl-tRNA synthetase multienzyme complex IEA
 cellular_componentGO:0097452 GAIT complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004818 glutamate-tRNA ligase activity IEA
 molecular_functionGO:0004827 proline-tRNA ligase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0035613 RNA stem-loop binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
SeMet incorporation into proteins
Cytosolic tRNA aminoacylation
tRNA modification in the nucleus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167264 DUS2 / Q9NX74 / dihydrouridine synthase 2  / complex






 

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