ENSMUSG00000026615


Mus musculus

Features
Gene ID: ENSMUSG00000026615
  
Biological name :Eprs
  
Synonyms : Eprs / Mus musculus glutamyl-prolyl-tRNA synthetase (Eprs), transcript variant 2, mRNA. / Q8CGC7
  
Possible biological names infered from orthology : glutamyl-prolyl-tRNA synthetase / P07814
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H5
Gene start: 185363044
Gene end: 185428360
  
Corresponding Affymetrix probe sets: 10352514 (MoGene1.0st)   1426713_s_at (Mouse Genome 430 2.0 Array)   1430370_at (Mouse Genome 430 2.0 Array)   1452157_at (Mouse Genome 430 2.0 Array)   1452158_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141550
Ensembl peptide - ENSMUSP00000045841
Ensembl peptide - ENSMUSP00000141467
NCBI entrez gene - 107508     See in Manteia.
MGI - MGI:97838
RefSeq - XM_017320653
RefSeq - NM_001357474
RefSeq - NM_029735
RefSeq - XM_006497117
RefSeq - XM_006497118
RefSeq Peptide - NP_084011
RefSeq Peptide - NP_001344403
swissprot - A0A0A6YWH3
swissprot - Q8CGC7
swissprot - A0A0A6YWA4
Ensembl - ENSMUSG00000026615
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eprsENSDARG00000060494Danio rerio
 EPRSENSGALG00000009598Gallus gallus
 EPRSENSG00000136628Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000738  WHEP-TRS domain
 IPR000924  Glutamyl/glutaminyl-tRNA synthetase
 IPR001412  Aminoacyl-tRNA synthetase, class I, conserved site
 IPR002314  Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
 IPR004046  Glutathione S-transferase, C-terminal
 IPR004154  Anticodon-binding
 IPR004499  Proline-tRNA ligase, class IIa, archaeal-type
 IPR004526  Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
 IPR006195  Aminoacyl-tRNA synthetase, class II
 IPR009068  S15/NS1, RNA-binding
 IPR011035  Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR016061  Proline-tRNA ligase, class II, C-terminal
 IPR017449  Prolyl-tRNA synthetase, class II
 IPR020056  Ribosomal protein L25/Gln-tRNA synthetase, N-terminal
 IPR020058  Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
 IPR020059  Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
 IPR020061  Glutamine-tRNA ligase, alpha-bundle domain superfamily
 IPR033721  Prolyl-tRNA synthetase, catalytic domain
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily
 IPR036621  Anticodon-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006424 glutamyl-tRNA aminoacylation IBA
 biological_processGO:0006433 prolyl-tRNA aminoacylation IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0043039 tRNA aminoacylation IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0017101 aminoacyl-tRNA synthetase multienzyme complex IEA
 cellular_componentGO:0097452 GAIT complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004818 glutamate-tRNA ligase activity IBA
 molecular_functionGO:0004827 proline-tRNA ligase activity IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0035613 RNA stem-loop binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009295 decreased interscapular fat pad weight 
Show

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009299 decreased mesenteric fat pad weight 
Show

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
Show

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0014173 increased fatty acid beta-oxidation "increased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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