ENSG00000167769


Homo sapiens

Features
Gene ID: ENSG00000167769
  
Biological name :ACER1
  
Synonyms : ACER1 / alkaline ceramidase 1 / Q8TDN7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 6306142
Gene end: 6333629
  
Corresponding Affymetrix probe sets: 1553929_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301452
NCBI entrez gene - 125981     See in Manteia.
OMIM - 613491
RefSeq - NM_133492
RefSeq - XM_011527673
RefSeq Peptide - NP_597999
swissprot - Q8TDN7
Ensembl - ENSG00000167769
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acer1ENSDARG00000010347Danio rerio
 ACER1ENSGALG00000001592Gallus gallus
 Acer1ENSMUSG00000045019Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACER2 / Q5QJU3 / alkaline ceramidase 2ENSG0000017707628


Protein motifs (from Interpro)
Interpro ID Name
 IPR008901  Ceramidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0008544 epidermis development IEP
 biological_processGO:0010446 response to alkaline pH IDA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IDA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030216 keratinocyte differentiation IEP
 biological_processGO:0046512 sphingosine biosynthetic process IDA
 biological_processGO:0046514 ceramide catabolic process IEA
 biological_processGO:0071277 cellular response to calcium ion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
 molecular_functionGO:0017040 N-acylsphingosine amidohydrolase activity IDA
 molecular_functionGO:0071633 dihydroceramidase activity IDA
 molecular_functionGO:0102121 ceramidase activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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