ENSG00000177076


Homo sapiens

Features
Gene ID: ENSG00000177076
  
Biological name :ACER2
  
Synonyms : ACER2 / alkaline ceramidase 2 / Q5QJU3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p22.1
Gene start: 19409059
Gene end: 19452020
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000342609
NCBI entrez gene - 340485     See in Manteia.
OMIM - 613492
RefSeq - XM_017014694
RefSeq - NM_001010887
RefSeq - XM_005251448
RefSeq - XM_011517859
RefSeq Peptide - NP_001010887
swissprot - Q5QJU3
Ensembl - ENSG00000177076
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acer2ENSDARG00000077782Danio rerio
 ACER2ENSGALG00000015081Gallus gallus
 Acer2ENSMUSG00000038007Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACER1 / Q8TDN7 / alkaline ceramidase 1ENSG0000016776927


Protein motifs (from Interpro)
Interpro ID Name
 IPR008901  Ceramidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010942 positive regulation of cell death IMP
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin IDA
 biological_processGO:0035690 cellular response to drug IEP
 biological_processGO:0046512 sphingosine biosynthetic process IDA
 biological_processGO:0090285 negative regulation of protein glycosylation in Golgi IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
 molecular_functionGO:0017040 N-acylsphingosine amidohydrolase activity TAS
 molecular_functionGO:0071633 dihydroceramidase activity IDA
 molecular_functionGO:0102121 ceramidase activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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