ENSMUSG00000038007


Mus musculus

Features
Gene ID: ENSMUSG00000038007
  
Biological name :Acer2
  
Synonyms : Acer2 / alkaline ceramidase 2 / Q8VD53
  
Possible biological names infered from orthology : Q5QJU3
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C4
Gene start: 86874396
Gene end: 86934822
  
Corresponding Affymetrix probe sets: 10505779 (MoGene1.0st)   10505788 (MoGene1.0st)   1421496_at (Mouse Genome 430 2.0 Array)   1451355_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040048
Ensembl peptide - ENSMUSP00000081473
NCBI entrez gene - 230379     See in Manteia.
MGI - MGI:1920932
RefSeq - XM_011250012
RefSeq - NM_001290541
RefSeq - NM_001290543
RefSeq - NM_139306
RefSeq - XM_006537877
RefSeq - XM_006537878
RefSeq Peptide - NP_001277470
RefSeq Peptide - NP_001277472
RefSeq Peptide - NP_647467
swissprot - Q8VD53
Ensembl - ENSMUSG00000038007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acer2ENSDARG00000077782Danio rerio
 ACER2ENSGALG00000015081Gallus gallus
 ACER2ENSG00000177076Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acer1 / Q8R4X1 / alkaline ceramidase 1 / Q8TDN7*ENSMUSG0000004501928


Protein motifs (from Interpro)
Interpro ID Name
 IPR008901  Ceramidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001953 negative regulation of cell-matrix adhesion ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010942 positive regulation of cell death ISO
 biological_processGO:0032526 response to retinoic acid ISO
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin ISO
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0046512 sphingosine biosynthetic process ISO
 biological_processGO:0090285 negative regulation of protein glycosylation in Golgi ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
 molecular_functionGO:0017040 N-acylsphingosine amidohydrolase activity ISO
 molecular_functionGO:0071633 dihydroceramidase activity ISO
 molecular_functionGO:0102121 ceramidase activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic Background: involves: 129

 MP:0012230 abnormal sphingolipid level 
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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