ENSG00000169245


Homo sapiens

Features
Gene ID: ENSG00000169245
  
Biological name :CXCL10
  
Synonyms : CXCL10 / C-X-C motif chemokine ligand 10 / P02778
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.1
Gene start: 76021117
Gene end: 76023497
  
Corresponding Affymetrix probe sets: 204533_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305651
NCBI entrez gene - 3627     See in Manteia.
OMIM - 147310
RefSeq - NM_001565
RefSeq Peptide - NP_001556
swissprot - A0A024RDA4
swissprot - P02778
Ensembl - ENSG00000169245
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Cxcl10ENSMUSG00000034855Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CXCL9 / Q07325 / C-X-C motif chemokine ligand 9ENSG0000013875537


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007517 muscle organ development TAS
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010818 T cell chemotaxis IMP
 biological_processGO:0010819 regulation of T cell chemotaxis IDA
 biological_processGO:0010996 response to auditory stimulus IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0042118 endothelial cell activation IGI
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IDA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IDA
 biological_processGO:1901509 regulation of endothelial tube morphogenesis IDA
 biological_processGO:1901740 negative regulation of myoblast fusion IEA
 biological_processGO:2000406 positive regulation of T cell migration IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0008201 heparin binding IMP
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity TAS
 molecular_functionGO:0048248 CXCR3 chemokine receptor binding IDA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000186810 CXCR3 / P49682 / C-X-C motif chemokine receptor 3  / complex / reaction






 

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