ENSG00000169397


Homo sapiens

Features
Gene ID: ENSG00000169397
  
Biological name :RNASE3
  
Synonyms : P12724 / ribonuclease A family member 3 / RNASE3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q11.2
Gene start: 20891399
Gene end: 20892348
  
Corresponding Affymetrix probe sets: 206851_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302324
NCBI entrez gene - 6037     See in Manteia.
OMIM - 131398
RefSeq - NM_002935
RefSeq Peptide - NP_002926
swissprot - P12724
Ensembl - ENSG00000169397
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ear1ENSMUSG00000072601Mus musculus
 Ear10ENSMUSG00000090166Mus musculus
 Ear14ENSMUSG00000050766Mus musculus
 Ear2ENSMUSG00000072596Mus musculus
 Ear6ENSMUSG00000062148Mus musculus
 O35292ENSMUSG00000059606Mus musculus
 Rnase2aENSMUSG00000047222Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P10153 / RNASE2 / ribonuclease A family member 2ENSG0000016938569
Q93091 / RNASE6 / ribonuclease A family member k6ENSG0000016941340
Q9H1E1 / RNASE7 / ribonuclease A family member 7ENSG0000016579938
Q8TDE3 / RNASE8 / ribonuclease A family member 8ENSG0000017343136


Protein motifs (from Interpro)
Interpro ID Name
 IPR001427  Pancreatic ribonuclease
 IPR023411  Ribonuclease A, active site
 IPR023412  Ribonuclease A-domain
 IPR036816  Ribonuclease A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002227 innate immune response in mucosa IDA
 biological_processGO:0006401 RNA catabolic process TAS
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043152 induction of bacterial agglutination IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IBA
 molecular_functionGO:0004540 ribonuclease activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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