ENSG00000169621


Homo sapiens

Features
Gene ID: ENSG00000169621
  
Biological name :APLF
  
Synonyms : APLF / aprataxin and PNKP like factor / Q8IW19
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p13.3
Gene start: 68467561
Gene end: 68655862
  
Corresponding Affymetrix probe sets: 1555100_at (Human Genome U133 Plus 2.0 Array)   241379_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377874
Ensembl peptide - ENSP00000307004
Ensembl peptide - ENSP00000432297
Ensembl peptide - ENSP00000393403
NCBI entrez gene - 10887     See in Manteia.
NCBI entrez gene - 200558     See in Manteia.
OMIM - 607122
OMIM - 611035
RefSeq - NM_138964
RefSeq - NM_173545
RefSeq Peptide - NP_620414
RefSeq Peptide - NP_775816
swissprot - Q8IW19
swissprot - F8WET0
swissprot - E9PRH6
Ensembl - ENSG00000169621
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:165656ENSDARG00000096566Danio rerio
 APLFENSGALG00000008745Gallus gallus
 AplfENSMUSG00000030051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000611  Neuropeptide Y receptor family
 IPR008984  SMAD/FHA domain superfamily
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR019406  Zinc finger, C2H2, APLF-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0045191 regulation of isotype switching IEA
 biological_processGO:0051106 positive regulation of DNA ligation IGI
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035861 site of double-strand break IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IDA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004983 neuropeptide Y receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008408 3"-5" exonuclease activity IDA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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