ENSMUSG00000030051


Mus musculus

Features
Gene ID: ENSMUSG00000030051
  
Biological name :Aplf
  
Synonyms : Aplf / Aprataxin and PNK-like factor / Q9D842
  
Possible biological names infered from orthology : aprataxin and PNKP like factor / Q8IW19
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 87628424
Gene end: 87672193
  
Corresponding Affymetrix probe sets: 10546031 (MoGene1.0st)   1419773_at (Mouse Genome 430 2.0 Array)   1430297_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032130
Ensembl peptide - ENSMUSP00000066232
Ensembl peptide - ENSMUSP00000145358
NCBI entrez gene - 72103     See in Manteia.
MGI - MGI:1919353
RefSeq - XM_017321755
RefSeq - NM_001170489
RefSeq - NM_024251
RefSeq - XM_006506656
RefSeq - XM_006506657
RefSeq Peptide - NP_001163960
RefSeq Peptide - NP_077213
swissprot - Q9D842
swissprot - A0A0N4SW39
Ensembl - ENSMUSG00000030051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:165656ENSDARG00000096566Danio rerio
 APLFENSGALG00000008745Gallus gallus
 APLFENSG00000169621Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR008984  SMAD/FHA domain superfamily
 IPR019406  Zinc finger, C2H2, APLF-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0045191 regulation of isotype switching IMP
 biological_processGO:0051106 positive regulation of DNA ligation IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 molecular_functionGO:0000166 nucleotide binding ISO
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
 molecular_functionGO:0004520 endodeoxyribonuclease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pawrtm1Rang/Pawrtm1Rang
Genetic Background: C57BL/6NTac-Pawrtm1Rang

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Pawrtm1Rang/Pawrtm1Rang
Genetic Background: C57BL/6NTac-Pawrtm1Rang

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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