ENSG00000170893


Homo sapiens

Features
Gene ID: ENSG00000170893
  
Biological name :TRH
  
Synonyms : P20396 / thyrotropin releasing hormone / TRH
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q22.1
Gene start: 129974305
Gene end: 129977938
  
Corresponding Affymetrix probe sets: 206622_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000303452
Ensembl peptide - ENSP00000426522
NCBI entrez gene - 7200     See in Manteia.
OMIM - 613879
RefSeq - NM_007117
RefSeq Peptide - NP_009048
swissprot - D6RFM1
swissprot - P20396
Ensembl - ENSG00000170893
  
Related genetic diseases (OMIM): 275120 - Thyrotropin-releasing hormone deficiency, 275120
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trhENSDARG00000006868Danio rerio
 TRHENSGALG00000008490Gallus gallus
 TrhENSMUSG00000005892Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008857  Thyrotropin-releasing hormone


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001692 histamine metabolic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014050 negative regulation of glutamate secretion IEA
 biological_processGO:0014054 positive regulation of gamma-aminobutyric acid secretion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:2000252 negative regulation of feeding behavior IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008437 thyrotropin-releasing hormone activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000958 Dry skin 
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 HP:0001249 Mental retardation 
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 HP:0001324 Muscle weakness "Reduced strength of muscles." [HPO:curators]
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 HP:0001609 Hoarse voice 
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 HP:0002019 Constipation 
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 HP:0002750 Delayed skeletal maturation "A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body." [HPO:curators]
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 HP:0004322 Decreased body height "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." [HPO:curators]
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 HP:0008237 Hypothalamic hypothyroidism 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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