ENSMUSG00000005892


Mus musculus

Features
Gene ID: ENSMUSG00000005892
  
Biological name :Trh
  
Synonyms : Pro-thyrotropin-releasing hormone Thyrotropin-releasing hormone / Q62361 / Trh
  
Possible biological names infered from orthology : P20396 / thyrotropin releasing hormone
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 92242061
Gene end: 92244650
  
Corresponding Affymetrix probe sets: 10546417 (MoGene1.0st)   1418756_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006046
NCBI entrez gene - 22044     See in Manteia.
MGI - MGI:98823
RefSeq - NM_009426
RefSeq Peptide - NP_033452
swissprot - Q62361
Ensembl - ENSMUSG00000005892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trhENSDARG00000006868Danio rerio
 TRHENSGALG00000008490Gallus gallus
 TRHENSG00000170893Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008857  Thyrotropin-releasing hormone


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001692 histamine metabolic process IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007628 adult walking behavior IGI
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014050 negative regulation of glutamate secretion IEA
 biological_processGO:0014054 positive regulation of gamma-aminobutyric acid secretion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:2000252 negative regulation of feeding behavior IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008437 thyrotropin-releasing hormone activity ISO


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005119 decreased circulating thyroid-stimulating hormone level "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0005135 increased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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