ENSG00000171109


Homo sapiens

Features
Gene ID: ENSG00000171109
  
Biological name :MFN1
  
Synonyms : MFN1 / mitofusin 1 / Q8IWA4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q26.33
Gene start: 179347692
Gene end: 179394931
  
Corresponding Affymetrix probe sets: 207098_s_at (Human Genome U133 Plus 2.0 Array)   211801_x_at (Human Genome U133 Plus 2.0 Array)   217043_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349963
Ensembl peptide - ENSP00000420617
Ensembl peptide - ENSP00000420148
Ensembl peptide - ENSP00000419926
Ensembl peptide - ENSP00000419134
Ensembl peptide - ENSP00000263969
NCBI entrez gene - 55669     See in Manteia.
OMIM - 608506
RefSeq - XM_011512963
RefSeq - NM_033540
RefSeq - XM_005247596
RefSeq Peptide - NP_284941
swissprot - H7C5H5
swissprot - C9JXQ1
swissprot - Q8IWA4
swissprot - A0A0C4DFN1
swissprot - C9JQT7
Ensembl - ENSG00000171109
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MFN1ENSDARG00000011884Danio rerio
 mfn1bENSDARG00000079219Danio rerio
 MFN1ENSGALG00000041873Gallus gallus
 Mfn1ENSMUSG00000027668Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MFN2 / O95140 / mitofusin 2ENSG0000011668862


Protein motifs (from Interpro)
Interpro ID Name
 IPR006884  Fzo/mitofusin HR2 domain
 IPR022812  Dynamin superfamily
 IPR027088  Mitofusin-1
 IPR027094  Mitofusin family
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0046039 GTP metabolic process IDA
 biological_processGO:0051646 mitochondrion localization IMP
 biological_processGO:1990613 mitochondrial membrane fusion IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IDA
 cellular_componentGO:0098799 outer mitochondrial membrane protein complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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