ENSMUSG00000027668


Mus musculus

Features
Gene ID: ENSMUSG00000027668
  
Biological name :Mfn1
  
Synonyms : Mfn1 / Mitofusin-1 / Q811U4
  
Possible biological names infered from orthology : Q8IWA4
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 32529465
Gene end: 32579239
  
Corresponding Affymetrix probe sets: 10491363 (MoGene1.0st)   1426773_at (Mouse Genome 430 2.0 Array)   1449697_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116380
Ensembl peptide - ENSMUSP00000120960
Ensembl peptide - ENSMUSP00000117411
Ensembl peptide - ENSMUSP00000088801
Ensembl peptide - ENSMUSP00000113251
NCBI entrez gene - 67414     See in Manteia.
MGI - MGI:1914664
RefSeq - NM_024200
RefSeq Peptide - NP_077162
swissprot - D3Z4L5
swissprot - F6XRI9
swissprot - D3Z5P8
swissprot - Q811U4
Ensembl - ENSMUSG00000027668
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MFN1ENSDARG00000011884Danio rerio
 mfn1bENSDARG00000079219Danio rerio
 MFN1ENSGALG00000041873Gallus gallus
 MFN1ENSG00000171109Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mfn2 / Q80U63 / Mus musculus mitofusin 2 (Mfn2), transcript variant 7, mRNA. / O95140* / mitofusin 2*ENSMUSG0000002902065


Protein motifs (from Interpro)
Interpro ID Name
 IPR006884  Fzo/mitofusin HR2 domain
 IPR022812  Dynamin superfamily
 IPR027088  Mitofusin-1
 IPR027094  Mitofusin family
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0046039 GTP metabolic process ISS
 biological_processGO:0051646 mitochondrion localization IBA
 biological_processGO:1990613 mitochondrial membrane fusion ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031306 intrinsic component of mitochondrial outer membrane IBA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane ISO
 cellular_componentGO:0098799 outer mitochondrial membrane protein complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn1tm1.1Arte/Mfn1tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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