ENSMUSG00000029020


Mus musculus

Features
Gene ID: ENSMUSG00000029020
  
Biological name :Mfn2
  
Synonyms : Mfn2 / Mus musculus mitofusin 2 (Mfn2), transcript variant 7, mRNA. / Q80U63
  
Possible biological names infered from orthology : mitofusin 2 / O95140
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 147873599
Gene end: 147904704
  
Corresponding Affymetrix probe sets: 10518385 (MoGene1.0st)   1448131_at (Mouse Genome 430 2.0 Array)   1451900_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117758
Ensembl peptide - ENSMUSP00000101341
Ensembl peptide - ENSMUSP00000123021
Ensembl peptide - ENSMUSP00000030884
Ensembl peptide - ENSMUSP00000101339
Ensembl peptide - ENSMUSP00000101340
NCBI entrez gene - 170731     See in Manteia.
MGI - MGI:2442230
RefSeq - XM_017320014
RefSeq - NM_001285920
RefSeq - NM_001285921
RefSeq - NM_001285922
RefSeq - NM_001285923
RefSeq - NM_001355590
RefSeq - NM_001355591
RefSeq - NM_133201
RefSeq - XM_006538609
RefSeq - XM_006538610
RefSeq - XM_006538611
RefSeq Peptide - NP_001272850
RefSeq Peptide - NP_001272851
RefSeq Peptide - NP_001272852
RefSeq Peptide - NP_001342519
RefSeq Peptide - NP_001342520
RefSeq Peptide - NP_573464
RefSeq Peptide - NP_001272849
swissprot - A2A7Y8
swissprot - A8Y5E5
swissprot - Q80U63
Ensembl - ENSMUSG00000029020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mfn2ENSDARG00000079504Danio rerio
 MFN2ENSGALG00000004523Gallus gallus
 MFN2ENSG00000116688Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mfn1 / Q811U4 / Mitofusin-1 / Q8IWA4*ENSMUSG0000002766864


Protein motifs (from Interpro)
Interpro ID Name
 IPR006884  Fzo/mitofusin HR2 domain
 IPR022812  Dynamin superfamily
 IPR027089  Mitofusin-2
 IPR027094  Mitofusin family
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001825 blastocyst formation IMP
 biological_processGO:0006626 protein targeting to mitochondrion ISO
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007006 mitochondrial membrane organization ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0034497 protein localization to phagophore assembly site ISO
 biological_processGO:0046580 negative regulation of Ras protein signal transduction ISO
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051646 mitochondrion localization IBA
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IMP
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031306 intrinsic component of mitochondrial outer membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfn2tm1.1Balo/Mfn2tm1.1Balo
Genetic Background: Not Specified

Allelic Composition: Mfn2tm2Dcc/Mfn2tm2Dcc
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

Allelic Composition: Mfn2tm2Dcc/Mfn2tm2Dcc
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

Allelic Composition: Mfn2tm1.1Balo/Mfn2tm1.1Balo
Genetic Background: Not Specified

Allelic Composition: Mfn2tm2Dcc/Mfn2tm2Dcc
Genetic Background: involves: 129S/SvEv

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Mfn2tm1Dcc/Mfn2tm3Dcc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: En1tm2(cre)Wrst/En1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mfn2tm1.1Balo/Mfn2tm1.1Balo
Genetic Background: Not Specified

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0011392 increased fetal cardiomyocyte apoptosis "increase in the number of fetal cardiomyocytes undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011633 abnormal mitochondrial shape "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013219 abnormal substantia nigra pars compacta morphology "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]
Show

Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029020 Mfn2 / Q80U63 / Mus musculus mitofusin 2 (Mfn2), transcript variant 7, mRNA. / O95140* / mitofusin 2*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr