ENSDARG00000079504


Danio rerio

Features
Gene ID: ENSDARG00000079504
  
Biological name :mfn2
  
Synonyms : mfn2 / mitofusin 2
  
Possible biological names infered from orthology : Mus musculus mitofusin 2 (Mfn2), transcript variant 7, mRNA. / O95140 / Q80U63
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 47897734
Gene end: 47948903
  
Corresponding Affymetrix probe sets: Dr.646.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000123285
NCBI entrez gene - 567448     See in Manteia.
RefSeq - XM_005172483
RefSeq - XM_005172484
RefSeq - NM_001128254
RefSeq Peptide - NP_001121726
swissprot - A8WIN6
ZFIN ID - ZDB-GENE-081105-44
Ensembl - ENSDARG00000079504
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MFN2ENSGALG00000004523Gallus gallus
 MFN2ENSG00000116688Homo sapiens
 Mfn2ENSMUSG00000029020Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mfn1b / mitofusin 1b / MFN1* / Q8IWA4* / Q811U4* / mitofusin 1*ENSDARG0000007921963
MFN1 / mitofusin 1 / Q8IWA4*ENSDARG0000001188436


Protein motifs (from Interpro)
Interpro ID Name
 IPR006884  Fzo/mitofusin HR2 domain
 IPR022812  Dynamin superfamily
 IPR027089  Mitofusin-2
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0008053 mitochondrial fusion IBA
 biological_processGO:0019896 axonal transport of mitochondrion IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0031306 intrinsic component of mitochondrial outer membrane IBA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain edematous , abnormal
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 ZFA:0000084 yolk yolk distended , abnormal
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 ZFA:0000094 blood island blood island has fewer parts of type hematopoietic stem cell , abnormal
blood island has fewer parts of type neutrophil , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000155 somite somite irregular spatial pattern , abnormal
somite decreased thickness , abnormal
somite U-shaped , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism movement behavioral quality , abnormal
whole organism decreased length , abnormal
whole organism decreased weight , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head necrotic , abnormal
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 ZFA:0001115 trunk trunk edematous , abnormal
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 ZFA:0001117 post-vent region post-vent region increased curvature , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
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 ZFA:0005180 RoP motor neuron RoP motor neuron decreased length , abnormal
RoP motor neuron immature , abnormal
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 ZFA:0009046 T cell T cell decreased amount , abnormal
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 ZFA:0009052 motor neuron motor neuron presynaptic active zone decreased area , abnormal
motor neuron axon absent , abnormal
motor neuron axon truncated , abnormal
motor neuron axon branchiness , abnormal
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 ZFA:0009063 peripheral neuron peripheral neuron axon guidance process quality , abnormal
peripheral neuron axon morphology , abnormal
peripheral neuron axon shape , abnormal
peripheral neuron axon branchiness , abnormal
peripheral neuron axon absent , abnormal
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 ZFA:0009114 muscle cell muscle cell neuromuscular junction decreased area , abnormal
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 ZFA:0009115 skeletal muscle cell skeletal muscle cell myofibril decreased thickness , abnormal
skeletal muscle cell myofibril disorganized , abnormal
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 ZFA:0009243 CaP motoneuron CaP motoneuron disorganized , abnormal
CaP motoneuron branchiness , abnormal
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 ZFA:0009248 neuron neuron mitochondrion circular , abnormal
neuron mitochondrion mislocalised , abnormal
neuron mitochondrion localization decreased process quality , abnormal
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 ZFA:0009323 thrombocyte thrombocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000079504 mfn2 / mitofusin 2 / O95140* / Q80U63* / Mus musculus mitofusin 2 (Mfn2), transcript variant 7, mRNA.*  / complex / reaction






 

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contact: otassy@igbmc.fr