ENSG00000172954


Homo sapiens

Features
Gene ID: ENSG00000172954
  
Biological name :LCLAT1
  
Synonyms : LCLAT1 / lysocardiolipin acyltransferase 1 / Q6UWP7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p23.1
Gene start: 30447226
Gene end: 30644225
  
Corresponding Affymetrix probe sets: 226996_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368826
Ensembl peptide - ENSP00000420481
Ensembl peptide - ENSP00000419966
Ensembl peptide - ENSP00000419735
Ensembl peptide - ENSP00000419646
Ensembl peptide - ENSP00000419444
Ensembl peptide - ENSP00000417951
Ensembl peptide - ENSP00000417875
Ensembl peptide - ENSP00000417565
Ensembl peptide - ENSP00000310551
Ensembl peptide - ENSP00000368823
NCBI entrez gene - 253558     See in Manteia.
OMIM - 614241
RefSeq - XM_017003746
RefSeq - XM_011532745
RefSeq - XM_005264244
RefSeq - XM_011532744
RefSeq - XM_011532743
RefSeq - XM_011532742
RefSeq - XM_011532741
RefSeq - NM_001002257
RefSeq - NM_001304445
RefSeq - NM_001304446
RefSeq - NM_182551
RefSeq - XM_017003747
RefSeq - XM_005264245
RefSeq Peptide - NP_001002257
RefSeq Peptide - NP_001291374
RefSeq Peptide - NP_001291375
RefSeq Peptide - NP_872357
swissprot - Q6UWP7
swissprot - C9K0C3
swissprot - F8WEY2
swissprot - C9J5S5
swissprot - C9J6F4
swissprot - C9JA02
swissprot - C9JMW2
swissprot - C9JUV9
swissprot - C9JXY8
Ensembl - ENSG00000172954
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lclat1ENSDARG00000103320Danio rerio
 LCLAT1ENSGALG00000009056Gallus gallus
 Lclat1ENSMUSG00000054469Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGPAT3 / Q9NRZ7 / 1-acylglycerol-3-phosphate O-acyltransferase 3ENSG0000016021623
AGPAT4 / Q9NRZ5 / 1-acylglycerol-3-phosphate O-acyltransferase 4ENSG0000002665222
AGPAT5 / Q9NUQ2 / 1-acylglycerol-3-phosphate O-acyltransferase 5ENSG0000015518919


Protein motifs (from Interpro)
Interpro ID Name
 IPR002123  Phospholipid/glycerol acyltransferase
 IPR032098  Acyltransferase, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0016024 CDP-diacylglycerol biosynthetic process IEA
 biological_processGO:0035965 cardiolipin acyl-chain remodeling TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008374 O-acyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of CL
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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