ENSMUSG00000054469


Mus musculus

Features
Gene ID: ENSMUSG00000054469
  
Biological name :Lclat1
  
Synonyms : Lclat1 / Lysocardiolipin acyltransferase 1 / Q3UN02
  
Possible biological names infered from orthology : Q6UWP7
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E1.3
Gene start: 73107985
Gene end: 73243368
  
Corresponding Affymetrix probe sets: 10446771 (MoGene1.0st)   1434690_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116535
Ensembl peptide - ENSMUSP00000119291
Ensembl peptide - ENSMUSP00000068690
NCBI entrez gene - 225010     See in Manteia.
MGI - MGI:2684937
RefSeq - XM_011246410
RefSeq - NM_001081071
RefSeq - NM_001177967
RefSeq - NM_001177968
RefSeq Peptide - NP_001171438
RefSeq Peptide - NP_001074540
RefSeq Peptide - NP_001171439
swissprot - Q3UN02
swissprot - B0V2Q9
swissprot - B0V2Q7
swissprot - B0V2Q8
Ensembl - ENSMUSG00000054469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lclat1ENSDARG00000103320Danio rerio
 LCLAT1ENSGALG00000009056Gallus gallus
 LCLAT1ENSG00000172954Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agpat3 / Q9D517 / 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma / Q9NRZ7* / 1-acylglycerol-3-phosphate O-acyltransferase 3*ENSMUSG0000000121125
Agpat4 / Q8K4X7 / 1-acyl-sn-glycerol-3-phosphate acyltransferase delta / Q9NRZ5* / 1-acylglycerol-3-phosphate O-acyltransferase 4*ENSMUSG0000002382724
Agpat5 / Q9D1E8 / 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon / Q9NUQ2* / 1-acylglycerol-3-phosphate O-acyltransferase 5*ENSMUSG0000003146721


Protein motifs (from Interpro)
Interpro ID Name
 IPR002123  Phospholipid/glycerol acyltransferase
 IPR032098  Acyltransferase, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0016024 CDP-diacylglycerol biosynthetic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of CL
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lclat1tm1Arai/Lclat1tm1Arai
Genetic Background: C57BL/6-Lclat1tm1Arai

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009122 decreased white fat cell lipid droplet size "reduction in the size of the single large lipid droplet or vacuole of white fat cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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