ENSMUSG00000001211


Mus musculus

Features
Gene ID: ENSMUSG00000001211
  
Biological name :Agpat3
  
Synonyms : 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma / Agpat3 / Q9D517
  
Possible biological names infered from orthology : 1-acylglycerol-3-phosphate O-acyltransferase 3 / Q9NRZ7
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 78269178
Gene end: 78352489
  
Corresponding Affymetrix probe sets: 10370471 (MoGene1.0st)   1433817_at (Mouse Genome 430 2.0 Array)   1433818_at (Mouse Genome 430 2.0 Array)   1433819_s_at (Mouse Genome 430 2.0 Array)   1450504_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114657
Ensembl peptide - ENSMUSP00000151528
Ensembl peptide - ENSMUSP00000132954
Ensembl peptide - ENSMUSP00000121052
Ensembl peptide - ENSMUSP00000119713
Ensembl peptide - ENSMUSP00000114885
Ensembl peptide - ENSMUSP00000001240
Ensembl peptide - ENSMUSP00000101026
Ensembl peptide - ENSMUSP00000101027
Ensembl peptide - ENSMUSP00000101028
Ensembl peptide - ENSMUSP00000101029
NCBI entrez gene - 28169     See in Manteia.
MGI - MGI:1336186
RefSeq - XM_006513719
RefSeq - XM_006513720
RefSeq - XM_006513721
RefSeq - XM_006513722
RefSeq - XM_006513723
RefSeq - NM_053014
RefSeq - XM_006513717
RefSeq - XM_006513718
RefSeq - XM_006513716
RefSeq Peptide - NP_443747
swissprot - Q9D517
swissprot - D3YV65
swissprot - D3YUW0
swissprot - D3YTN7
swissprot - A0A1W2P764
swissprot - D3Z1M6
Ensembl - ENSMUSG00000001211
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agpat3ENSDARG00000036549Danio rerio
 AGPAT3ENSGALG00000031932Gallus gallus
 AGPAT3ENSG00000160216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agpat4 / Q8K4X7 / 1-acyl-sn-glycerol-3-phosphate acyltransferase delta / Q9NRZ5* / 1-acylglycerol-3-phosphate O-acyltransferase 4*ENSMUSG0000002382760
Lclat1 / Q3UN02 / Lysocardiolipin acyltransferase 1 / Q6UWP7*ENSMUSG0000005446925
Agpat5 / Q9D1E8 / 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon / Q9NUQ2* / 1-acylglycerol-3-phosphate O-acyltransferase 5*ENSMUSG0000003146722


Protein motifs (from Interpro)
Interpro ID Name
 IPR002123  Phospholipid/glycerol acyltransferase
 IPR032098  Acyltransferase, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0016024 CDP-diacylglycerol biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0042171 lysophosphatidic acid acyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Synthesis of PA
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chattm2(cre)Lowl/Chat+,Mecp2tm2Bird/Y
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Chattm2(cre)Lowl/Chat+,Mecp2tm2Bird/Y
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Chattm2(cre)Lowl/Chat+,Mecp2tm2Bird/Y
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Chattm2(cre)Lowl/Chat+,Mecp2tm2Bird/Y
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chattm2(cre)Lowl/Chat+,Mecp2tm2Bird/Y
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chattm2(cre)Lowl/Chat+,Mecp2tm2Bird/Y
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chattm2(cre)Lowl/Chat+,Mecp2tm2Bird/Y
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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