ENSMUSG00000023827


Mus musculus

Features
Gene ID: ENSMUSG00000023827
  
Biological name :Agpat4
  
Synonyms : 1-acyl-sn-glycerol-3-phosphate acyltransferase delta / Agpat4 / Q8K4X7
  
Possible biological names infered from orthology : 1-acylglycerol-3-phosphate O-acyltransferase 4 / Q9NRZ5
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 12118704
Gene end: 12219645
  
Corresponding Affymetrix probe sets: 10441740 (MoGene1.0st)   1428336_at (Mouse Genome 430 2.0 Array)   1436640_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024594
Ensembl peptide - ENSMUSP00000128085
Ensembl peptide - ENSMUSP00000127477
Ensembl peptide - ENSMUSP00000127417
NCBI entrez gene - 68262     See in Manteia.
MGI - MGI:1915512
RefSeq - XM_006523345
RefSeq - XM_006523348
RefSeq - XM_006523347
RefSeq - NM_026644
RefSeq Peptide - NP_080920
swissprot - Q8K4X7
swissprot - E9Q6S5
swissprot - E9Q2T9
swissprot - E9Q2W7
Ensembl - ENSMUSG00000023827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agpat4ENSDARG00000069044Danio rerio
 AGPAT4ENSGALG00000011571Gallus gallus
 AGPAT4ENSG00000026652Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agpat3 / Q9D517 / 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma / Q9NRZ7* / 1-acylglycerol-3-phosphate O-acyltransferase 3*ENSMUSG0000000121160
Lclat1 / Q3UN02 / Lysocardiolipin acyltransferase 1 / Q6UWP7*ENSMUSG0000005446924
Agpat5 / Q9D1E8 / 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon / Q9NUQ2* / 1-acylglycerol-3-phosphate O-acyltransferase 5*ENSMUSG0000003146720


Protein motifs (from Interpro)
Interpro ID Name
 IPR002123  Phospholipid/glycerol acyltransferase
 IPR032098  Acyltransferase, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0016024 CDP-diacylglycerol biosynthetic process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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