ENSG00000173698


Homo sapiens

Features
Gene ID: ENSG00000173698
  
Biological name :ADGRG2
  
Synonyms : ADGRG2 / adhesion G protein-coupled receptor G2 / Q8IZP9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p22.13
Gene start: 18989309
Gene end: 19122637
  
Corresponding Affymetrix probe sets: 206002_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369207
Ensembl peptide - ENSP00000344972
Ensembl peptide - ENSP00000346845
Ensembl peptide - ENSP00000349015
Ensembl peptide - ENSP00000350152
Ensembl peptide - ENSP00000350680
Ensembl peptide - ENSP00000353421
Ensembl peptide - ENSP00000369198
Ensembl peptide - ENSP00000369202
Ensembl peptide - ENSP00000369205
NCBI entrez gene - 10149     See in Manteia.
OMIM - 300572
RefSeq - XM_011545435
RefSeq - NM_001079858
RefSeq - NM_001079859
RefSeq - NM_001079860
RefSeq - NM_001184833
RefSeq - NM_001184834
RefSeq - NM_001184835
RefSeq - NM_001184836
RefSeq - NM_001184837
RefSeq - NM_005756
RefSeq - XM_006724455
RefSeq - XM_011545434
RefSeq Peptide - NP_001073329
RefSeq Peptide - NP_001171763
RefSeq Peptide - NP_001171764
RefSeq Peptide - NP_001171765
RefSeq Peptide - NP_001171766
RefSeq Peptide - NP_005747
RefSeq Peptide - NP_001171762
RefSeq Peptide - NP_001073327
RefSeq Peptide - NP_001073328
swissprot - Q8IZP9
Ensembl - ENSG00000173698
  
Related genetic diseases (OMIM): 300985 - Vas deferens, congenital bilateral aplasia of, X-linked, 300985
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgrg2aENSDARG00000088137Danio rerio
 si:dkey-259j3.5ENSDARG00000088937Danio rerio
 ADGRG2ENSGALG00000016511Gallus gallus
 Adgrg2ENSMUSG00000031298Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADGRG6 / Q86SQ4 / adhesion G protein-coupled receptor G6ENSG0000011241434
ADGRG4 / Q8IZF6 / adhesion G protein-coupled receptor G4ENSG0000015692032
ADGRG1 / Q9Y653 / adhesion G protein-coupled receptor G1ENSG0000020533617
ADGRG3 / Q86Y34 / adhesion G protein-coupled receptor G3ENSG0000018288516
ADGRG5 / Q8IZF4 / adhesion G protein-coupled receptor G5ENSG0000015961814
ADGRG7 / Q96K78 / adhesion G protein-coupled receptor G7ENSG0000014482014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007283 spermatogenesis TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000027 Azoospermia 
Show

 HP:0000798 Oligospermia 
Show

 HP:0001417 X-linked inheritance "A mode of inheritance that is observed for traits related to a gene encoded on the X chromosome." [HPO:curators]
Show

 HP:0003251 Male infertility 
Show

 HP:0011962 Obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
Show

 HP:0012210 Abnormal renal morphology "Any structural anomaly of the `kidney` (FMA:7203)." [HPO:probinson]
Show

 HP:0012873 Absent vas deferens "Aplasia (congenital absence) of the vas deferens." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr