ENSG00000175197


Homo sapiens

Features
Gene ID: ENSG00000175197
  
Biological name :DDIT3
  
Synonyms : DDIT3 / DNA damage inducible transcript 3 / P35638
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 57516588
Gene end: 57521737
  
Corresponding Affymetrix probe sets: 209383_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494844
Ensembl peptide - ENSP00000447803
Ensembl peptide - ENSP00000448665
Ensembl peptide - ENSP00000340671
Ensembl peptide - ENSP00000447188
Ensembl peptide - ENSP00000447503
NCBI entrez gene - 1649     See in Manteia.
OMIM - 126337
RefSeq - NM_001195055
RefSeq - NM_001195053
RefSeq - NM_001195054
RefSeq - NM_001195056
RefSeq - NM_001195057
RefSeq - NM_004083
RefSeq Peptide - NP_001181982
RefSeq Peptide - NP_004074
RefSeq Peptide - NP_001181983
RefSeq Peptide - NP_001181984
RefSeq Peptide - NP_001181985
RefSeq Peptide - NP_001181986
swissprot - P35638
swissprot - F8W133
swissprot - Q53YD1
Ensembl - ENSG00000175197
  
Related genetic diseases (OMIM): 613488 - Myxoid liposarcoma, 613488

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddit3ENSDARG00000059836Danio rerio
 Ddit3ENSMUSG00000025408Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR016670  DNA damage-inducible transcript 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001955 blood vessel maturation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus TAS
 biological_processGO:0006983 ER overload response IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IMP
 biological_processGO:0032792 negative regulation of CREB transcription factor activity IGI
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0036500 ATF6-mediated unfolded protein response TAS
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IC
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress TAS
 biological_processGO:0044324 regulation of transcription involved in anterior/posterior axis specification ISS
 biological_processGO:0045454 cell redox homeostasis IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
 biological_processGO:0072655 establishment of protein localization to mitochondrion IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISS
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IC
 biological_processGO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISS
 biological_processGO:1990442 intrinsic apoptotic signaling pathway in response to nitrosative stress IEA
 biological_processGO:2000016 negative regulation of determination of dorsal identity IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032993 protein-DNA complex IDA
 cellular_componentGO:0035976 transcription factor AP-1 complex ISS
 cellular_componentGO:0036488 CHOP-C/EBP complex TAS
 cellular_componentGO:1990617 CHOP-ATF4 complex IPI
 cellular_componentGO:1990622 CHOP-ATF3 complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IGI
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008140 cAMP response element binding protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043522 leucine zipper domain binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity TAS


Pathways (from Reactome)
Pathway description
ATF4 activates genes
ATF6 (ATF6-alpha) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001428 Somatic mutation 
Show

 HP:0001482 Subcutaneous nodules 
Show

 HP:0002027 Abdominal pain 
Show

 HP:0002579 Gastrointestinal dysmotility 
Show

 HP:0012268 Myxoid liposarcoma "A liposarcoma that contains myxomatous tissue." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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