ENSMUSG00000025408


Mus musculus

Features
Gene ID: ENSMUSG00000025408
  
Biological name :Ddit3
  
Synonyms : Ddit3 / DNA damage-inducible transcript 3 protein / P35639
  
Possible biological names infered from orthology : DNA damage inducible transcript 3 / P35638
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 127290774
Gene end: 127296288
  
Corresponding Affymetrix probe sets: 10366881 (MoGene1.0st)   1417516_at (Mouse Genome 430 2.0 Array)   1443897_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026475
Ensembl peptide - ENSMUSP00000118339
NCBI entrez gene - 13198     See in Manteia.
MGI - MGI:109247
RefSeq - XM_017313791
RefSeq - NM_001290183
RefSeq - NM_007837
RefSeq - XM_006513197
RefSeq Peptide - NP_031863
RefSeq Peptide - NP_001277112
swissprot - P35639
swissprot - D3YX14
Ensembl - ENSMUSG00000025408
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddit3ENSDARG00000059836Danio rerio
 DDIT3ENSG00000175197Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR016670  DNA damage-inducible transcript 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001955 blood vessel maturation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006983 ER overload response IMP
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032792 negative regulation of CREB transcription factor activity IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0042594 response to starvation IDA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IGI
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0044324 regulation of transcription involved in anterior/posterior axis specification IDA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IGI
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0072655 establishment of protein localization to mitochondrion IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:1901216 positive regulation of neuron death IMP
 biological_processGO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 biological_processGO:1990442 intrinsic apoptotic signaling pathway in response to nitrosative stress IDA
 biological_processGO:2000016 negative regulation of determination of dorsal identity IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0035976 transcription factor AP-1 complex IPI
 cellular_componentGO:0036488 CHOP-C/EBP complex IPI
 cellular_componentGO:1990617 CHOP-ATF4 complex IEA
 cellular_componentGO:1990622 CHOP-ATF3 complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008140 cAMP response element binding protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043522 leucine zipper domain binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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