ENSG00000175216


Homo sapiens

Features
Gene ID: ENSG00000175216
  
Biological name :CKAP5
  
Synonyms : CKAP5 / cytoskeleton associated protein 5 / Q14008
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p11.2
Gene start: 46743048
Gene end: 46846308
  
Corresponding Affymetrix probe sets: 1555278_a_at (Human Genome U133 Plus 2.0 Array)   212832_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434523
Ensembl peptide - ENSP00000436052
Ensembl peptide - ENSP00000436769
Ensembl peptide - ENSP00000310227
Ensembl peptide - ENSP00000346566
Ensembl peptide - ENSP00000431509
Ensembl peptide - ENSP00000432768
NCBI entrez gene - 9793     See in Manteia.
OMIM - 611142
RefSeq - NM_014756
RefSeq - NM_001008938
RefSeq Peptide - NP_001008938
RefSeq Peptide - NP_055571
swissprot - E9PQH5
swissprot - Q14008
swissprot - H0YCF6
swissprot - H0YDX5
swissprot - H0YEK7
Ensembl - ENSG00000175216
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ckap5ENSDARG00000102674Danio rerio
 CKAP5ENSGALG00000008325Gallus gallus
 Ckap5ENSMUSG00000040549Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008942  ENTH/VHS
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2
 IPR024395  CLASP N-terminal domain
 IPR034085  TOG domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0007019 microtubule depolymerization TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0030951 establishment or maintenance of microtubule cytoskeleton polarity IMP
 biological_processGO:0046785 microtubule polymerization IBA
 biological_processGO:0050658 RNA transport ISS
 biological_processGO:0051298 centrosome duplication IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0000930 gamma-tubulin complex IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0015630 microtubule cytoskeleton ISS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035371 microtubule plus-end IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051010 microtubule plus-end binding IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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