ENSMUSG00000040549


Mus musculus

Features
Gene ID: ENSMUSG00000040549
  
Biological name :Ckap5
  
Synonyms : Ckap5 / cytoskeleton associated protein 5
  
Possible biological names infered from orthology : Q14008
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 91526762
Gene end: 91620664
  
Corresponding Affymetrix probe sets: 10473919 (MoGene1.0st)   1430647_at (Mouse Genome 430 2.0 Array)   1437349_at (Mouse Genome 430 2.0 Array)   1442271_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046263
Ensembl peptide - ENSMUSP00000097303
Ensembl peptide - ENSMUSP00000106969
Ensembl peptide - ENSMUSP00000106970
NCBI entrez gene - 75786     See in Manteia.
MGI - MGI:1923036
RefSeq - NM_001165989
RefSeq - NM_029437
RefSeq - XM_006500342
RefSeq - XM_006500343
RefSeq - XM_006500344
RefSeq Peptide - NP_083713
RefSeq Peptide - NP_001159461
swissprot - K3W4R5
swissprot - A0A0R4J0K2
swissprot - Z4YL78
Ensembl - ENSMUSG00000040549
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ckap5ENSDARG00000102674Danio rerio
 CKAP5ENSGALG00000008325Gallus gallus
 CKAP5ENSG00000175216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008942  ENTH/VHS
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2
 IPR024395  CLASP N-terminal domain
 IPR034085  TOG domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0030951 establishment or maintenance of microtubule cytoskeleton polarity IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0000930 gamma-tubulin complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035371 microtubule plus-end IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S1/Sv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S1/Sv

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0013140 excessive vocalization "producing sound from the vocal organs more frequently or more loudly than expected" [MGI:Ahmad_Retha]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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