ENSG00000176720


Homo sapiens

Features
Gene ID: ENSG00000176720
  
Biological name :BOK
  
Synonyms : BOK / BOK, BCL2 family apoptosis regulator / Q9UMX3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.3
Gene start: 241551424
Gene end: 241574138
  
Corresponding Affymetrix probe sets: 223349_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000314132
NCBI entrez gene - 666     See in Manteia.
OMIM - 605404
RefSeq - XM_017004776
RefSeq - NM_032515
RefSeq - XM_011511696
RefSeq - XM_017004775
RefSeq Peptide - NP_115904
swissprot - A0A024R4A8
swissprot - Q9UMX3
Ensembl - ENSG00000176720
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bokaENSDARG00000052129Danio rerio
 BOKENSGALG00000005772Gallus gallus
 BokENSMUSG00000026278Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR026298  Blc2 family
 IPR026309  Bcl-2-related ovarian killer protein
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0006921 cellular component disassembly involved in execution phase of apoptosis ISS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation IEP
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c ISS
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0051259 protein complex oligomerization ISS
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0051902 negative regulation of mitochondrial depolarization IEA
 biological_processGO:0060546 negative regulation of necroptotic process IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IMP
 biological_processGO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IEA
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
 biological_processGO:1901382 regulation of chorionic trophoblast cell proliferation IDA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISS
 biological_processGO:1903899 positive regulation of PERK-mediated unfolded protein response ISS
 biological_processGO:1904708 regulation of granulosa cell apoptotic process IMP
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane ISS
 cellular_componentGO:0031966 mitochondrial membrane IDA
 cellular_componentGO:0032588 trans-Golgi network membrane ISS
 cellular_componentGO:0033106 cis-Golgi network membrane ISS
 cellular_componentGO:0055038 recycling endosome membrane ISS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IBA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051400 BH domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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