ENSMUSG00000026278


Mus musculus

Features
Gene ID: ENSMUSG00000026278
  
Biological name :Bok
  
Synonyms : Bcl-2-related ovarian killer protein / Bok / O35425
  
Possible biological names infered from orthology : BOK, BCL2 family apoptosis regulator / Q9UMX3
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 93685660
Gene end: 93695764
  
Corresponding Affymetrix probe sets: 10348858 (MoGene1.0st)   1417040_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140412
Ensembl peptide - ENSMUSP00000144347
Ensembl peptide - ENSMUSP00000144146
Ensembl peptide - ENSMUSP00000027499
NCBI entrez gene - 51800     See in Manteia.
MGI - MGI:1858494
RefSeq - NM_016778
RefSeq Peptide - NP_058058
swissprot - A0A087WR00
swissprot - A0A0J9YUF0
swissprot - O35425
swissprot - Q3TH93
Ensembl - ENSMUSG00000026278
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bokaENSDARG00000052129Danio rerio
 BOKENSGALG00000005772Gallus gallus
 BOKENSG00000176720Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR026298  Blc2 family
 IPR026309  Bcl-2-related ovarian killer protein
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria ISO
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0006921 cellular component disassembly involved in execution phase of apoptosis IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
 biological_processGO:0010506 regulation of autophagy ISO
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0051402 neuron apoptotic process IDA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0051902 negative regulation of mitochondrial depolarization IMP
 biological_processGO:0060546 negative regulation of necroptotic process IMP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator ISO
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis ISO
 biological_processGO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
 biological_processGO:1901382 regulation of chorionic trophoblast cell proliferation ISO
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903899 positive regulation of PERK-mediated unfolded protein response IMP
 biological_processGO:1904708 regulation of granulosa cell apoptotic process ISO
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane ISO
 cellular_componentGO:0032588 trans-Golgi network membrane IDA
 cellular_componentGO:0033106 cis-Golgi network membrane IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IBA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051400 BH domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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