ENSG00000181195


Homo sapiens

Features
Gene ID: ENSG00000181195
  
Biological name :PENK
  
Synonyms : P01210 / PENK / proenkephalin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q12.1
Gene start: 56436674
Gene end: 56446734
  
Corresponding Affymetrix probe sets: 213791_at (Human Genome U133 Plus 2.0 Array)   237774_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430268
Ensembl peptide - ENSP00000324248
Ensembl peptide - ENSP00000430592
Ensembl peptide - ENSP00000400894
Ensembl peptide - ENSP00000429326
Ensembl peptide - ENSP00000428012
NCBI entrez gene - 5179     See in Manteia.
OMIM - 131330
RefSeq - NM_001135690
RefSeq Peptide - NP_001129162
swissprot - E5RFR1
swissprot - A0A024R7V4
swissprot - H0YBT5
swissprot - E5RJ72
swissprot - P01210
swissprot - E5RIP6
Ensembl - ENSG00000181195
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 penkaENSDARG00000004869Danio rerio
 penkbENSDARG00000036045Danio rerio
 PENKENSGALG00000015419Gallus gallus
 PenkENSMUSG00000045573Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDYN / P01213 / prodynorphinENSG0000010132728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000703  Proenkephalin A
 IPR006024  Opioid neuropeptide precursor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0002118 aggressive behavior IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007600 sensory perception IBA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051867 general adaptation syndrome, behavioral process IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071871 response to epinephrine IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:2000987 positive regulation of behavioral fear response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IBA
 cellular_componentGO:0032280 symmetric synapse IEA
 cellular_componentGO:0043025 neuronal cell body IBA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IBA
 cellular_componentGO:0070852 cell body fiber IEA
 molecular_functionGO:0001515 opioid peptide activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity TAS
 molecular_functionGO:0031628 opioid receptor binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (i) signalling events
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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