ENSMUSG00000045573


Mus musculus

Features
Gene ID: ENSMUSG00000045573
  
Biological name :Penk
  
Synonyms : P22005 / Penk / Proenkephalin-A Synenkephalin Met-enkephalin PENK(114-133) PENK(143-184) Met-enkephalin-Arg-Ser-Leu Leu-enkephalin PENK(238-259) Met-enkephalin-Arg-Phe
  
Possible biological names infered from orthology : P01210 / proenkephalin
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A1
Gene start: 4133531
Gene end: 4138819
  
Corresponding Affymetrix probe sets: 10511363 (MoGene1.0st)   1427038_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066822
Ensembl peptide - ENSMUSP00000122389
NCBI entrez gene - 18619     See in Manteia.
MGI - MGI:104629
RefSeq - XM_006537675
RefSeq - NM_001002927
RefSeq Peptide - NP_001002927
RefSeq Peptide - NP_001335138
swissprot - P22005
swissprot - B1AZQ0
Ensembl - ENSMUSG00000045573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 penkaENSDARG00000004869Danio rerio
 penkbENSDARG00000036045Danio rerio
 PENKENSGALG00000015419Gallus gallus
 PENKENSG00000181195Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdyn / prodynorphin / P01213*ENSMUSG0000002740027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000703  Proenkephalin A
 IPR006024  Opioid neuropeptide precursor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001964 startle response IMP
 biological_processGO:0002118 aggressive behavior IMP
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051867 general adaptation syndrome, behavioral process IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071871 response to epinephrine IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:2000987 positive regulation of behavioral fear response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032280 symmetric synapse IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0070852 cell body fiber IEA
 molecular_functionGO:0001515 opioid peptide activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IBA
 molecular_functionGO:0031628 opioid receptor binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (i) signalling events
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Tab1tm1.1Mis/Tab1tm1.1Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tab1tm1.1Mis/Tab1tm1.1Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001980 abnormal chemically-elicited antinociception "change in the analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Tab1tm1.1Mis/Tab1tm1.1Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0006415 absent testes "absence of the male reproductive glands containing the germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tab1tm1.1Mis/Tab1tm1.1Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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