ENSG00000181847


Homo sapiens

Features
Gene ID: ENSG00000181847
  
Biological name :TIGIT
  
Synonyms : Q495A1 / T cell immunoreceptor with Ig and ITIM domains / TIGIT
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q13.31
Gene start: 114276913
Gene end: 114310288
  
Corresponding Affymetrix probe sets: 240070_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373167
Ensembl peptide - ENSP00000420552
Ensembl peptide - ENSP00000419706
Ensembl peptide - ENSP00000419085
Ensembl peptide - ENSP00000418917
NCBI entrez gene - 201633     See in Manteia.
OMIM - 612859
RefSeq - XM_011512538
RefSeq - NM_173799
RefSeq Peptide - NP_776160
swissprot - C9J0B0
swissprot - C9JZW6
swissprot - Q495A1
swissprot - A0A0C4DGA4
Ensembl - ENSG00000181847
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TigitENSMUSG00000071552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0032695 negative regulation of interleukin-12 production IMP
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0050868 negative regulation of T cell activation IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0050839 cell adhesion molecule binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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