ENSMUSG00000071552


Mus musculus

Features
Gene ID: ENSMUSG00000071552
  
Biological name :Tigit
  
Synonyms : T cell immunoreceptor with Ig and ITIM domains / Tigit
  
Possible biological names infered from orthology : Q495A1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B4
Gene start: 43648861
Gene end: 43664184
  
Corresponding Affymetrix probe sets: 10439527 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000093770
NCBI entrez gene - 100043314     See in Manteia.
MGI - MGI:3642260
RefSeq - NM_001146325
RefSeq Peptide - NP_001139797
swissprot - A0A0B4J1G6
Ensembl - ENSMUSG00000071552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIGITENSG00000181847Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032695 negative regulation of interleukin-12 production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tigittm1Sdl/Tigittm1Sdl,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tigittm1Sdl/Tigittm1Sdl,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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