ENSG00000183495


Homo sapiens

Features
Gene ID: ENSG00000183495
  
Biological name :EP400
  
Synonyms : E1A binding protein p400 / EP400 / Q96L91
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.33
Gene start: 131949920
Gene end: 132081102
  
Corresponding Affymetrix probe sets: 212375_at (Human Genome U133 Plus 2.0 Array)   212376_s_at (Human Genome U133 Plus 2.0 Array)   230628_at (Human Genome U133 Plus 2.0 Array)   230629_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000330620
Ensembl peptide - ENSP00000374213
Ensembl peptide - ENSP00000374212
Ensembl peptide - ENSP00000333602
Ensembl peptide - ENSP00000331737
NCBI entrez gene - 57634     See in Manteia.
OMIM - 606265
RefSeq - NM_015409
RefSeq Peptide - NP_056224
swissprot - A0A0A0MR72
swissprot - A0A0A0MR70
swissprot - A0A0A0MR80
swissprot - Q96L91
Ensembl - ENSG00000183495
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ep400ENSDARG00000100965Danio rerio
 ENSGALG00000002336Gallus gallus
 Ep400ENSMUSG00000029505Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SRCAP / Q6ZRS2 / Snf2 related CREBBP activator proteinENSG0000008060324
AC106886.5ENSG0000028203423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014012  Helicase/SANT-associated domain
 IPR017877  Myb-like domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031575  E1A-binding protein p400, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0043967 histone H4 acetylation IDA
 biological_processGO:0043968 histone H2A acetylation IDA
 cellular_componentGO:0000812 Swr1 complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016607 nuclear speck ISS
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:1990405 protein antigen binding IEA


Pathways (from Reactome)
Pathway description
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
DNA Damage/Telomere Stress Induced Senescence
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex






 

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