ENSMUSG00000029505


Mus musculus

Features
Gene ID: ENSMUSG00000029505
  
Biological name :Ep400
  
Synonyms : E1A-binding protein p400 / Ep400 / Q8CHI8
  
Possible biological names infered from orthology : Q96L91
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 110664373
Gene end: 110770717
  
Corresponding Affymetrix probe sets: 10532407 (MoGene1.0st)   1426860_at (Mouse Genome 430 2.0 Array)   1437020_at (Mouse Genome 430 2.0 Array)   1440751_at (Mouse Genome 430 2.0 Array)   1447349_s_at (Mouse Genome 430 2.0 Array)   1447712_x_at (Mouse Genome 430 2.0 Array)   1449610_at (Mouse Genome 430 2.0 Array)   1453130_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138369
Ensembl peptide - ENSMUSP00000108055
Ensembl peptide - ENSMUSP00000116137
Ensembl peptide - ENSMUSP00000049038
Ensembl peptide - ENSMUSP00000108052
Ensembl peptide - ENSMUSP00000108054
NCBI entrez gene - 75560     See in Manteia.
MGI - MGI:1276124
RefSeq - XM_017321135
RefSeq - XM_017321129
RefSeq - XM_017321130
RefSeq - XM_017321131
RefSeq - XM_017321132
RefSeq - XM_017321133
RefSeq - XM_017321134
RefSeq - NM_029337
RefSeq - NM_173066
RefSeq - XM_006535265
RefSeq - XM_006535269
RefSeq - XM_006535270
RefSeq - XM_006535271
RefSeq - XM_006535276
RefSeq - XM_006535277
RefSeq Peptide - NP_083613
RefSeq Peptide - NP_775089
swissprot - F6R9G0
swissprot - Q8CHI8
swissprot - D3Z6R8
swissprot - Q641K9
Ensembl - ENSMUSG00000029505
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ep400ENSDARG00000100965Danio rerio
 ENSGALG00000002336Gallus gallus
 EP400ENSG00000183495Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srcap / Snf2-related CREBBP activator protein / Q6ZRS2* / AC106886.5*ENSMUSG0000005387724
Gm42715 / SRCAP* / Q6ZRS2* / AC106886.5* / Snf2 related CREBBP activator protein*ENSMUSG0000010702323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014012  Helicase/SANT-associated domain
 IPR017877  Myb-like domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031575  E1A-binding protein p400, N-terminal
 IPR035500  Nuclear hormone receptor-like domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0043967 histone H4 acetylation ISO
 biological_processGO:0043968 histone H2A acetylation ISO
 cellular_componentGO:0000812 Swr1 complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:1990405 protein antigen binding IEA


Pathways (from Reactome)
Pathway description
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
DNA Damage/Telomere Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000215 absent erythrocytes "lack of mature red blood cells" [J:23061]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex






 

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