ENSG00000186652


Homo sapiens

Features
Gene ID: ENSG00000186652
  
Biological name :PRG2
  
Synonyms : P13727 / PRG2 / proteoglycan 2, pro eosinophil major basic protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.1
Gene start: 57386794
Gene end: 57390657
  
Corresponding Affymetrix probe sets: 211743_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312134
Ensembl peptide - ENSP00000433016
Ensembl peptide - ENSP00000433231
NCBI entrez gene - 5553     See in Manteia.
OMIM - 605601
RefSeq - NM_001302927
RefSeq - NM_001243245
RefSeq - NM_001302926
RefSeq - NM_002728
RefSeq Peptide - NP_001230174
RefSeq Peptide - NP_001289855
RefSeq Peptide - NP_001289856
RefSeq Peptide - NP_002719
swissprot - P13727
Ensembl - ENSG00000186652
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PGR2/3ENSGALG00000043860Gallus gallus
 Prg2ENSMUSG00000027073Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRG3 / Q9Y2Y8 / proteoglycan 3, pro eosinophil major basic protein 2ENSG0000015657548


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR002352  Eosinophil major basic protein
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033816  Eosinophil major basic protein, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002215 defense response to nematode IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0032693 negative regulation of interleukin-10 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0042035 regulation of cytokine biosynthetic process IBA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0030246 carbohydrate binding TAS


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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