ENSG00000188372


Homo sapiens

Features
Gene ID: ENSG00000188372
  
Biological name :ZP3
  
Synonyms : P21754 / zona pellucida glycoprotein 3 / ZP3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q11.23
Gene start: 76397518
Gene end: 76442071
  
Corresponding Affymetrix probe sets: 204148_s_at (Human Genome U133 Plus 2.0 Array)   210910_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411955
Ensembl peptide - ENSP00000337310
Ensembl peptide - ENSP00000378326
Ensembl peptide - ENSP00000378329
NCBI entrez gene - 7784     See in Manteia.
OMIM - 182889
RefSeq - XM_017012586
RefSeq - NM_001110354
RefSeq - NM_007155
RefSeq Peptide - NP_001103824
RefSeq Peptide - NP_009086
swissprot - E9PFI9
swissprot - H0Y3M4
swissprot - P21754
Ensembl - ENSG00000188372
  
Related genetic diseases (OMIM): 617712 - Oocyte maturation defect 3, 617712
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR759892.1ENSDARG00000115457Danio rerio
 zgc:171779ENSDARG00000016908Danio rerio
 zp3.2ENSDARG00000114958Danio rerio
 zp3.2ENSDARG00000090768Danio rerio
 zp3a.1ENSDARG00000042129Danio rerio
 zp3a.2ENSDARG00000042130Danio rerio
 zp3bENSDARG00000039828Danio rerio
 ENSGALG00000001721Gallus gallus
 ENSGALG00000045179Gallus gallus
 ZP3ENSGALG00000001559Gallus gallus
 Zp3ENSMUSG00000004948Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
POMZP3 / Q6PJE2 / POM121 and ZP3 fusionENSG0000014670727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001507  Zona pellucida domain
 IPR017977  Zona pellucida domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001809 positive regulation of type IV hypersensitivity ISS
 biological_processGO:0001825 blastocyst formation ISS
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin ISS
 biological_processGO:0002687 positive regulation of leukocyte migration ISS
 biological_processGO:0002922 positive regulation of humoral immune response IDA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007339 binding of sperm to zona pellucida TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process ISS
 biological_processGO:0032729 positive regulation of interferon-gamma production ISS
 biological_processGO:0032753 positive regulation of interleukin-4 production ISS
 biological_processGO:0035803 egg coat formation IBA
 biological_processGO:0042102 positive regulation of T cell proliferation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048015 phosphatidylinositol-mediated signaling ISS
 biological_processGO:0048599 oocyte development ISS
 biological_processGO:0050729 positive regulation of inflammatory response ISS
 biological_processGO:2000344 positive regulation of acrosome reaction IDA
 biological_processGO:2000360 negative regulation of binding of sperm to zona pellucida IDA
 biological_processGO:2000368 positive regulation of acrosomal vesicle exocytosis IMP
 biological_processGO:2000386 positive regulation of ovarian follicle development ISS
 biological_processGO:2000388 positive regulation of antral ovarian follicle growth ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IDA
 molecular_functionGO:0032190 acrosin binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0048018 receptor ligand activity ISS


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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