ENSMUSG00000004948


Mus musculus

Features
Gene ID: ENSMUSG00000004948
  
Biological name :Zp3
  
Synonyms : P10761 / zona pellucida glycoprotein 3 / Zp3
  
Possible biological names infered from orthology : P21754 / POM121 and ZP3 fusion / POMZP3 / Q6PJE2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 135980099
Gene end: 135988624
  
Corresponding Affymetrix probe sets: 10526418 (MoGene1.0st)   1419007_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005073
Ensembl peptide - ENSMUSP00000120447
NCBI entrez gene - 22788     See in Manteia.
MGI - MGI:99215
RefSeq - NM_011776
RefSeq Peptide - NP_035906
swissprot - F6VD35
swissprot - P10761
Ensembl - ENSMUSG00000004948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR759892.1ENSDARG00000115457Danio rerio
 zgc:171779ENSDARG00000016908Danio rerio
 zp3.2ENSDARG00000114958Danio rerio
 zp3.2ENSDARG00000090768Danio rerio
 zp3a.1ENSDARG00000042129Danio rerio
 zp3a.2ENSDARG00000042130Danio rerio
 zp3bENSDARG00000039828Danio rerio
 ENSGALG00000045179Gallus gallus
 ENSGALG00000001721Gallus gallus
 ZP3ENSGALG00000001559Gallus gallus
 POMZP3ENSG00000146707Homo sapiens
 ZP3ENSG00000188372Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001507  Zona pellucida domain
 IPR017977  Zona pellucida domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001809 positive regulation of type IV hypersensitivity IDA
 biological_processGO:0001825 blastocyst formation IMP
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin IDA
 biological_processGO:0002687 positive regulation of leukocyte migration IDA
 biological_processGO:0002922 positive regulation of humoral immune response ISO
 biological_processGO:0007339 binding of sperm to zona pellucida IMP
 biological_processGO:0010469 regulation of signaling receptor activity IMP
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0032753 positive regulation of interleukin-4 production IDA
 biological_processGO:0035803 egg coat formation IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IMP
 biological_processGO:0048599 oocyte development IMP
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0090280 positive regulation of calcium ion import IDA
 biological_processGO:2000344 positive regulation of acrosome reaction ISO
 biological_processGO:2000360 negative regulation of binding of sperm to zona pellucida ISO
 biological_processGO:2000368 positive regulation of acrosomal vesicle exocytosis ISO
 biological_processGO:2000386 positive regulation of ovarian follicle development IMP
 biological_processGO:2000388 positive regulation of antral ovarian follicle growth IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding ISO
 molecular_functionGO:0032190 acrosin binding ISO
 molecular_functionGO:0035804 structural constituent of egg coat IMP
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0048018 receptor ligand activity IMP


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0003697 absent zona pellucida "missing the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009372 abnormal cumulus oophorus "atypical formation of or inability to produce a mass of epithelial granulosa cells around the oocyte in the maturing Graafian follicle; the cumulus oophorus begins to expand dramatically when cumulus cells are induced to synthesize hyaluronic acid which aggregates in a viscous intercellular matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009375 thin zona pellucida "reduced thickness of the solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Zp3tm1Dean/Zp3tm1Dean,Tg(ZP3)7812Dean/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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