ENSG00000189221


Homo sapiens

Features
Gene ID: ENSG00000189221
  
Biological name :MAOA
  
Synonyms : MAOA / monoamine oxidase A / P21397
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p11.3
Gene start: 43654907
Gene end: 43746824
  
Corresponding Affymetrix probe sets: 204388_s_at (Human Genome U133 Plus 2.0 Array)   204389_at (Human Genome U133 Plus 2.0 Array)   212741_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340684
Ensembl peptide - ENSP00000440846
NCBI entrez gene - 4128     See in Manteia.
OMIM - 309850
RefSeq - NM_001270458
RefSeq - NM_000240
RefSeq Peptide - NP_000231
RefSeq Peptide - NP_001257387
swissprot - P21397
swissprot - Q53YE7
Ensembl - ENSG00000189221
  
Related genetic diseases (OMIM): 300615 - Brunner syndrome, 300615
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maoENSDARG00000023712Danio rerio
 MAOAENSGALG00000016224Gallus gallus
 MaoaENSMUSG00000025037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAOB / P27338 / monoamine oxidase BENSG0000006953571


Protein motifs (from Interpro)
Interpro ID Name
 IPR001613  Flavin amine oxidase
 IPR002937  Amine oxidase
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006576 cellular biogenic amine metabolic process TAS
 biological_processGO:0006584 catecholamine metabolic process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0042133 neurotransmitter metabolic process TAS
 biological_processGO:0042135 neurotransmitter catabolic process IEA
 biological_processGO:0042420 dopamine catabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008131 primary amine oxidase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Norepinephrine Neurotransmitter Release Cycle
Enzymatic degradation of dopamine by COMT
Enzymatic degradation of Dopamine by monoamine oxidase
Metabolism of serotonin
Defective MAOA causes Brunner syndrome (BRUNS)
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000708 Behavioural/Psychiatric Abnormality 
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 HP:0000717 Autism 
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 HP:0000718 Aggressive behavior "Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself." [HPO:curators]
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 HP:0000744 Low frustration tolerance 
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 HP:0001249 Mental retardation 
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 HP:0001270 Motor retardation 
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 HP:0001419 X-linked recessive inheritance "A mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele." [HPO:curators]
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 HP:0100543 Cognitive impairment "Abnormality in the process of thought including the ability to process information." [HPO:sdoelken]
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 HP:0100716 Autoagression "Aggression towards oneself." [HPO:sdoelken]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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