ENSMUSG00000025037


Mus musculus

Features
Gene ID: ENSMUSG00000025037
  
Biological name :Maoa
  
Synonyms : Maoa / monoamine oxidase A / Q64133
  
Possible biological names infered from orthology : P21397
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.2
Gene start: 16619698
Gene end: 16687818
  
Corresponding Affymetrix probe sets: 10598771 (MoGene1.0st)   1428667_at (Mouse Genome 430 2.0 Array)   1442676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026013
NCBI entrez gene - 17161     See in Manteia.
MGI - MGI:96915
RefSeq - NM_173740
RefSeq Peptide - NP_776101
swissprot - Q64133
Ensembl - ENSMUSG00000025037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maoENSDARG00000023712Danio rerio
 MAOAENSGALG00000016224Gallus gallus
 MAOAENSG00000189221Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Maob / Q8BW75 / monoamine oxidase B / P27338*ENSMUSG0000004014769


Protein motifs (from Interpro)
Interpro ID Name
 IPR001613  Flavin amine oxidase
 IPR002937  Amine oxidase
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006584 catecholamine metabolic process IEA
 biological_processGO:0042135 neurotransmitter catabolic process IEA
 biological_processGO:0042420 dopamine catabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008131 primary amine oxidase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Norepinephrine Neurotransmitter Release Cycle
Enzymatic degradation of dopamine by COMT
Enzymatic degradation of Dopamine by monoamine oxidase
Metabolism of serotonin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/Y
Genetic Background: involves: C3H/HeJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaK284stop/Y
Genetic Background: 129S6/SvEvTac-MaoaK284stop

 MP:0001357 increased aggression to humans "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward humans" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0001400 hyperresponsive "increased reaction to touch" [J:39801]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Vdrtm1Mbd/Vdr+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001440 abnormal grooming behavior "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/Y
Genetic Background: involves: C3H/HeJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003360 depression-related behavior 
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Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/Y
Genetic Background: involves: C3H/HeJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/Y
Genetic Background: involves: C3H/HeJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/Y
Genetic Background: involves: C3H/HeJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/Y
Genetic Background: involves: C3H/HeJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/Y
Genetic Background: involves: C3H/HeJ

Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MaoaTg(H2-K1-Ifnb1)8Seif/?
Genetic Background: involves: C3H/HeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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