ENSMUSG00000040147


Mus musculus

Features
Gene ID: ENSMUSG00000040147
  
Biological name :Maob
  
Synonyms : Maob / monoamine oxidase B / Q8BW75
  
Possible biological names infered from orthology : P27338
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.2
Gene start: 16709282
Gene end: 16817366
  
Corresponding Affymetrix probe sets: 10603746 (MoGene1.0st)   1434354_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127235
Ensembl peptide - ENSMUSP00000134555
Ensembl peptide - ENSMUSP00000131743
Ensembl peptide - ENSMUSP00000040550
NCBI entrez gene - 109731     See in Manteia.
MGI - MGI:96916
RefSeq - NM_172778
RefSeq Peptide - NP_766366
swissprot - E9PVL9
swissprot - G3UZM5
swissprot - E9Q3X6
swissprot - Q8BW75
Ensembl - ENSMUSG00000040147
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maoENSDARG00000023712Danio rerio
 MAOBENSGALG00000032836Gallus gallus
 MAOBENSG00000069535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Maoa / Q64133 / monoamine oxidase A / P21397*ENSMUSG0000002503770


Protein motifs (from Interpro)
Interpro ID Name
 IPR001613  Flavin amine oxidase
 IPR002937  Amine oxidase
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010044 response to aluminum ion IEA
 biological_processGO:0010269 response to selenium ion IEA
 biological_processGO:0014063 negative regulation of serotonin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0042135 neurotransmitter catabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045964 positive regulation of dopamine metabolic process IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008131 primary amine oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Bace1tm1Bux/Bace1tm1Bux
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bace1tm1Bux/Bace1tm1Bux
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
Show

Allelic Composition: Bace1tm1Bux/Bace1tm1Bux
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr