ENSG00000189283


Homo sapiens

Features
Gene ID: ENSG00000189283
  
Biological name :FHIT
  
Synonyms : FHIT / fragile histidine triad / P49789
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p14.2
Gene start: 59749310
Gene end: 61251459
  
Corresponding Affymetrix probe sets: 206492_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418596
Ensembl peptide - ENSP00000342087
Ensembl peptide - ENSP00000417480
Ensembl peptide - ENSP00000417557
Ensembl peptide - ENSP00000418582
NCBI entrez gene - 2272     See in Manteia.
OMIM - 601153
RefSeq - XM_017005884
RefSeq - NM_001166243
RefSeq - NM_001320899
RefSeq - NM_001320900
RefSeq - NM_002012
RefSeq - XM_017005880
RefSeq - XM_017005881
RefSeq - XM_017005882
RefSeq - XM_017005883
RefSeq Peptide - NP_001307829
RefSeq Peptide - NP_002003
RefSeq Peptide - NP_001159715
RefSeq Peptide - NP_001307828
swissprot - P49789
swissprot - A0A0A0MRB0
swissprot - E9PBZ0
swissprot - A0A024R366
Ensembl - ENSG00000189283
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fhitENSDARG00000078195Danio rerio
 FHITENSDARG00000104993Danio rerio
 FHITENSGALG00000007172Gallus gallus
 FhitENSMUSG00000060579Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001310  Histidine triad (HIT) protein
 IPR011146  HIT-like domain
 IPR019808  Histidine triad, conserved site
 IPR036265  HIT-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006163 purine nucleotide metabolic process IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009117 nucleotide metabolic process TAS
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0047710 bis(5"-adenosyl)-triphosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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