ENSMUSG00000060579


Mus musculus

Features
Gene ID: ENSMUSG00000060579
  
Biological name :Fhit
  
Synonyms : Bis(5-adenosyl)-triphosphatase / Fhit / O89106
  
Possible biological names infered from orthology : fragile histidine triad / P49789
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A1
Gene start: 9550092
Gene end: 11162035
  
Corresponding Affymetrix probe sets: 10417605 (MoGene1.0st)   1425893_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124073
Ensembl peptide - ENSMUSP00000124500
Ensembl peptide - ENSMUSP00000136011
Ensembl peptide - ENSMUSP00000124957
Ensembl peptide - ENSMUSP00000123820
Ensembl peptide - ENSMUSP00000123874
Ensembl peptide - ENSMUSP00000124017
NCBI entrez gene - 14198     See in Manteia.
MGI - MGI:1277947
RefSeq - XM_006517924
RefSeq - XM_017315847
RefSeq - XM_011244732
RefSeq - XM_006517927
RefSeq - NM_001308285
RefSeq - NM_001308286
RefSeq - NM_010210
RefSeq Peptide - NP_001295214
RefSeq Peptide - NP_001295215
RefSeq Peptide - NP_034340
swissprot - O89106
swissprot - E9Q3M6
swissprot - E9PVU9
swissprot - F6SV10
swissprot - E9PZ91
Ensembl - ENSMUSG00000060579
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fhitENSDARG00000078195Danio rerio
 FHITENSDARG00000104993Danio rerio
 FHITENSGALG00000007172Gallus gallus
 FHITENSG00000189283Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001310  Histidine triad (HIT) protein
 IPR011146  HIT-like domain
 IPR019808  Histidine triad, conserved site
 IPR036265  HIT-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006163 purine nucleotide metabolic process ISO
 biological_processGO:0006260 DNA replication IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009117 nucleotide metabolic process TAS
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator ISS
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity TAS
 molecular_functionGO:0016787 hydrolase activity ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0047710 bis(5"-adenosyl)-triphosphatase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
Show

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Hint1tm1Tpm/Hint1tm1Tpm
Genetic Background: Not Specified

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fhittm1Hbn/Fhit+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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