ENSG00000197530


Homo sapiens

Features
Gene ID: ENSG00000197530
  
Biological name :MIB2
  
Synonyms : MIB2 / mindbomb E3 ubiquitin protein ligase 2 / Q96AX9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.33
Gene start: 1615415
Gene end: 1630610
  
Corresponding Affymetrix probe sets: 228261_at (Human Genome U133 Plus 2.0 Array)   241377_s_at (Human Genome U133 Plus 2.0 Array)   241378_at (Human Genome U133 Plus 2.0 Array)   241541_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426103
Ensembl peptide - ENSP00000426007
Ensembl peptide - ENSP00000426128
Ensembl peptide - ENSP00000464106
Ensembl peptide - ENSP00000463504
Ensembl peptide - ENSP00000428660
Ensembl peptide - ENSP00000428264
Ensembl peptide - ENSP00000427680
Ensembl peptide - ENSP00000426865
Ensembl peptide - ENSP00000426603
Ensembl peptide - ENSP00000348081
Ensembl peptide - ENSP00000367980
Ensembl peptide - ENSP00000367984
Ensembl peptide - ENSP00000420935
Ensembl peptide - ENSP00000423221
Ensembl peptide - ENSP00000424615
Ensembl peptide - ENSP00000425032
NCBI entrez gene - 142678     See in Manteia.
OMIM - 611141
RefSeq - XM_017000366
RefSeq - XM_011540742
RefSeq - XM_017000349
RefSeq - XM_017000350
RefSeq - XM_017000351
RefSeq - XM_017000352
RefSeq - XM_017000353
RefSeq - XM_017000354
RefSeq - XM_017000355
RefSeq - XM_017000356
RefSeq - XM_017000357
RefSeq - XM_017000358
RefSeq - XM_017000359
RefSeq - XM_017000360
RefSeq - XM_017000361
RefSeq - XM_017000362
RefSeq - XM_017000363
RefSeq - XM_017000364
RefSeq - XM_017000365
RefSeq - NM_001170686
RefSeq - NM_001170687
RefSeq - NM_001170688
RefSeq - NM_001170689
RefSeq - NM_080875
RefSeq - XM_006710372
RefSeq - XM_011540731
RefSeq - XM_011540736
RefSeq - XM_011540737
RefSeq - XM_011540741
RefSeq Peptide - NP_543151
RefSeq Peptide - NP_001164159
RefSeq Peptide - NP_001164160
RefSeq Peptide - NP_001164157
RefSeq Peptide - NP_001164158
swissprot - D6RDI1
swissprot - D6RAZ0
swissprot - F2Z2L2
swissprot - H0YAM8
swissprot - E9PD12
swissprot - J3QR95
swissprot - Q96AX9
swissprot - D6R9Q6
swissprot - J3QLE0
swissprot - D6RHY5
swissprot - D6RFJ2
swissprot - D6RED3
swissprot - D6RE96
Ensembl - ENSG00000197530
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MIB2ENSDARG00000103609Danio rerio
 MIB2ENSGALG00000001473Gallus gallus
 Mib2ENSMUSG00000029060Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MIB1 / Q86YT6 / mindbomb E3 ubiquitin protein ligase 1ENSG0000010175237
Q8WXD9 / CASKIN1 / CASK interacting protein 1ENSG0000016797113
Q8WXE0 / CASKIN2 / CASK interacting protein 2ENSG0000017730312
ANKS1A / Q92625 / ankyrin repeat and sterile alpha motif domain containing 1AENSG0000006499912
ANKS1B / Q7Z6G8 / ankyrin repeat and sterile alpha motif domain containing 1BENSG0000018504611
ANKRD6 / Q9Y2G4 / ankyrin repeat domain 6ENSG0000013529910
Q495B1 / ANKDD1A / ankyrin repeat and death domain containing 1AENSG0000016683910
A6NHY2 / ANKDD1B / ankyrin repeat and death domain containing 1BENSG000001890458


Protein motifs (from Interpro)
Interpro ID Name
 IPR000433  Zinc finger, ZZ-type
 IPR001841  Zinc finger, RING-type
 IPR002110  Ankyrin repeat
 IPR010606  Mib-herc2
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037252  Mib/herc2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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