ENSMUSG00000029060


Mus musculus

Features
Gene ID: ENSMUSG00000029060
  
Biological name :Mib2
  
Synonyms : E3 ubiquitin-protein ligase MIB2 / Mib2 / Q8R516
  
Possible biological names infered from orthology : mindbomb E3 ubiquitin protein ligase 2 / Q96AX9
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 155654677
Gene end: 155669198
  
Corresponding Affymetrix probe sets: 10519151 (MoGene1.0st)   1424862_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099465
Ensembl peptide - ENSMUSP00000122269
NCBI entrez gene - 76580     See in Manteia.
MGI - MGI:2679684
RefSeq - XM_017320438
RefSeq - NM_001256107
RefSeq - NM_001256108
RefSeq - NM_145124
RefSeq - XM_006539253
RefSeq - XM_006539254
RefSeq - XM_006539255
RefSeq - XM_011250353
RefSeq - XM_017320437
RefSeq - XM_006539247
RefSeq - XM_006539249
RefSeq - XM_006539250
RefSeq - XM_006539251
RefSeq - XM_006539252
RefSeq Peptide - NP_001243036
RefSeq Peptide - NP_001243037
RefSeq Peptide - NP_660106
swissprot - Q8R516
swissprot - A2A9P8
Ensembl - ENSMUSG00000029060
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MIB2ENSDARG00000103609Danio rerio
 MIB2ENSGALG00000001473Gallus gallus
 MIB2ENSG00000197530Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mib1 / Q80SY4 / E3 ubiquitin-protein ligase MIB1 / Q86YT6* / mindbomb E3 ubiquitin protein ligase 1*ENSMUSG0000002429440
Q6P9K8 / Caskin1 / Q8WXD9* / CASK interacting protein 1*ENSMUSG0000003359714
Anks1 / P59672 / Ankyrin repeat and SAM domain-containing protein 1A / Q92625* / ANKS1A* / ankyrin repeat and sterile alpha motif domain containing 1A*ENSMUSG0000002421914
Q8VHK1 / Caskin2 / Q8WXE0* / CASK interacting protein 2*ENSMUSG0000003447113
Ankrd6 / Q69ZU8 / Mus musculus ankyrin repeat domain 6 (Ankrd6), transcript variant 4, mRNA. / Q9Y2G4* / ankyrin repeat domain 6*ENSMUSG0000004018311
Ankdd1a / ankyrin repeat and death domain containing 1A / Q495B1*ENSMUSG0000006651011
Q14DN9 / Ankdd1b / Ankyrin repeat and death domain-containing protein 1B / A6NHY2* / ankyrin repeat and death domain containing 1B*ENSMUSG0000004711710
Anks1b / ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 6 / Q7Z6G8* / ankyrin repeat and sterile alpha motif domain containing 1B*ENSMUSG000000585895


Protein motifs (from Interpro)
Interpro ID Name
 IPR000433  Zinc finger, ZZ-type
 IPR001841  Zinc finger, RING-type
 IPR002110  Ankyrin repeat
 IPR010606  Mib-herc2
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037252  Mib/herc2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ets2tm2Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurl1atm1Ynj/Neurl1atm1Ynj,Neurl2tm1Kong/Neurl2tm1Kong
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Mib1tm1Kong/Mib1+,Mib2tm1Kong/Mib2tm1Kong
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mib1tm1Kong/Mib1+,Mib2tm1Kong/Mib2tm1Kong
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong,Mib2tm1Kong/Mib2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ets2tm2Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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